Camellia sinensis: Insights on its molecular mechanisms of action towards nutraceutical, anticancer potential and other therapeutic applications
Chaudhary P. Mitra D. Das Mohapatra P.K. Oana Docea A. Mon Myo E. Janmeda P. Martorell M. Iriti M. Ibrayeva M. Sharifi-Rad J. Santini A. Romano R. Calina D. Cho W.C.
May 2023Elsevier B.V.
Arabian Journal of Chemistry
2023#16Issue 5
The Camellia sinensis plant provides a wide diversity of black, green, oolong, yellow, brick dark, and white tea. Tea is one of the majorly used beverages across the globe, succeeds only in the water for fitness and pleasure. Generally, green tea has been preferred more as compared to other teas due to its main constituent e.g. polyphenols which contribute to various health benefits. The aim of this updated and comprehensive review is to bring together the latest data on the phytochemistry and pharmacological properties of Camellia sinensis and to highlight the therapeutic prospects of the bioactive compounds in this plant so that the full medicinal potential of Camellia sinensis can be realised. A review of published studies on this topic was performed by searching PubMed/MedLine, Scopus, Google scholar, and Web of Science databases from 1999 to 2022. The results of the analysed studies showed that the main polyphenols of tea are the four prime flavonoids catechins: epigallocatechin gallate (EGCG), epicatechin gallate (ECG), epigallocatechin (EGC), and epicatechin (EC) along with the beneficial biological properties of tea for a broad heterogeneity of disorders, including anticancer, neuroprotective, antibacterial, antiviral, antifungal, antiobesity, antidiabetes and antiglaucoma activities. Poor absorption and low bioavailability of bioactive compounds from Camellia sinensis are limiting aspects of their therapeutic use. More human clinical studies and approaching the latest nanoformulation techniques in nanoparticles to transport the target phytochemical compounds to increase therapeutic efficacy are needed in the future.
Camellia sinensis , Cellular mechanisms , Clinical applications , Molecular targets , Pharmacology , Signaling pathways
Text of the article Перейти на текст статьи
Department of Bioscience and Biotechnology, Banasthali Vidyapith, Rajasthan, 304022, India
Department of Microbiology, Raiganj University, West Bengal, Raiganj, 733134, India
Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania
Biotechnology Research Department, Ministry of Education, Mandalay Region, Kyaukse, Myanmar
Department of Nutrition and Dietetics, Faculty of Pharmacy, Centre for Healthy Living, University of Concepción, Concepción, 4070386, Chile
Department of Agricultural and Environmental Sciences, Università degli Studi di Milano, Italy
Faculty of Science and Technology, The Caspian University of Technology and Engineering named after Sh.Yessenov, Aktau, Kazakhstan
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador
Department of Pharmacy, University of Napoli Federico II, Via D. Montesano, 49, Napoli, 80131, Italy
Department of Agriculture, University of Napoli Federico II, Via Università 100, Portici (NA), 80055, Italy
Clinical Pharmacy Department, University of Medicine and Pharmacy of Craiova, Craiova, 200349, Romania
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Department of Bioscience and Biotechnology
Department of Microbiology
Department of Toxicology
Biotechnology Research Department
Department of Nutrition and Dietetics
Department of Agricultural and Environmental Sciences
Faculty of Science and Technology
Facultad de Medicina
Department of Pharmacy
Department of Agriculture
Clinical Pharmacy Department
Department of Clinical Oncology
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026