Methodological considerations in injury burden of disease studies across Europe: a systematic literature review

Charalampous P. Pallari E. Gorasso V. von der Lippe E. Devleesschauwer B. Pires S.M. Plass D. Idavain J. Ngwa C.H. Noguer I. Padron-Monedero A. Sarmiento R. Majdan M. Ádám B. AlKerwi A. Cilovic-Lagarija S. Clarsen B. Corso B. Cuschieri S. Dopelt K. Economou M. Fischer F. Freitas A. García-González J.M. Gazzelloni F. Gkitakou A. Gulmez H. Hynds P. Isola G. Jakobsen L.S. Kabir Z. Kissimova-Skarbek K. Knudsen A.K. Konar N.M. Ladeira C. Lassen B. Liew A. Majer M. Mechili E.A. Mereke A. Monasta L. Mondello S. Morgado J.N. Nena E. Ng E.S.W. Niranjan V. Nola I.A. O’Caoimh R. Petrou P. Pinheiro V. Ortiz M.R. Riva S. Samouda H. Santos J.V. Santoso C.M.A. Milicevic M.S. Skempes D. Sousa A.C. Speybroeck N. Tozija F. Unim B. Uysal H.B. Vaccaro F.G. Varga O. Vasic M. Violante F.S. Wyper G.M.A. Polinder S. Haagsma J.A.
December 2022 BioMed Central Ltd

BMC Public Health
2022 #22 Issue 1

Background: Calculating the disease burden due to injury is complex, as it requires many methodological choices. Until now, an overview of the methodological design choices that have been made in burden of disease (BoD) studies in injury populations is not available. The aim of this systematic literature review was to identify existing injury BoD studies undertaken across Europe and to comprehensively review the methodological design choices and assumption parameters that have been made to calculate years of life lost (YLL) and years lived with disability (YLD) in these studies. Methods: We searched EMBASE, MEDLINE, Cochrane Central, Google Scholar, and Web of Science, and the grey literature supplemented by handsearching, for BoD studies. We included injury BoD studies that quantified the BoD expressed in YLL, YLD, and disability-adjusted life years (DALY) in countries within the European Region between early-1990 and mid-2021. Results: We retrieved 2,914 results of which 48 performed an injury-specific BoD assessment. Single-country independent and Global Burden of Disease (GBD)-linked injury BoD studies were performed in 11 European countries. Approximately 79% of injury BoD studies reported the BoD by external cause-of-injury. Most independent studies used the incidence-based approach to calculate YLDs. About half of the injury disease burden studies applied disability weights (DWs) developed by the GBD study. Almost all independent injury studies have determined YLL using national life tables. Conclusions: Considerable methodological variation across independent injury BoD assessments was observed; differences were mainly apparent in the design choices and assumption parameters towards injury YLD calculations, implementation of DWs, and the choice of life table for YLL calculations. Development and use of guidelines for performing and reporting of injury BoD studies is crucial to enhance transparency and comparability of injury BoD estimates across Europe and beyond.

Burden of disease , Burden of Injury , Disability-adjusted life years , Methodology , Review

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Department of Public Health, Erasmus MC University Medical Center, Rotterdam, Netherlands
Health Innovation Network, Minerva House, Montague Close, London, United Kingdom
Department of Public Health and Primary Care, Ghent University, Ghent, Belgium
Department of Epidemiology and Public Health, Sciensano, Brussels, Belgium
Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany
Department of Translational Physiology, Infectiology and Public Health, Ghent University, Merelbeke, Belgium
National Food Institute, Technical University of Denmark, Lyngby, Denmark
Department for Exposure Assessment, and Environmental Health Indicators, German Environment Agency, Berlin, Germany
Department of Health Statistics, National Institute for Health Development, Tallinn, Estonia
School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Department of Epidemiology and Population Health, Faculty of Health Sciences, American University of Beirut, Beirut, Lebanon
National School of Public Health, Carlos III Institute of Health, Madrid, Spain
Medicine School, University of Applied and Environmental Sciences, Bogota, Colombia
Department of Public Health, Faculty of Health Sciences and Social Work, Trnava University, Trnava, Slovakia
Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
Department of Public Health and Epidemiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Directorate of Health, Service Epidemiology and Statistics, Luxembourg, Luxembourg
Institute for Public Health FB&H, Sarajevo, Sarajevo, Bosnia and Herzegovina
Sports Trauma Research Center, Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway
Department of Disease Burden, Norwegian Institute of Public Health, Bergen, Norway
Department of Health and Functioning, Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Bergen, Norway
Institute of Neuroscience, National Research Council, Rome, Italy
Department of Anatomy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
Department of Public Health, Ashkelon Academic College, Ashkelon, Israel
Department of Health Policy and Management, School of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel
Department of Nursing, School of Health Sciences, Cyprus University of Technology, Limassol, Cyprus
Institute of Public Health, Charité - Universitätsmedizin Berlin, Berlin, Germany
CINTESIS – Center for Health Technology and Services Research, Faculty of Medicine, University of Porto, Porto, Portugal
Department of Community Medicine, Information and Health Decision Sciences (MEDCIDS), Faculty of Medicine, University of Porto, Porto, Portugal
Department of Sociology, Universidad Pablo de Olavide, Seville, Spain
Institute and Faculty of Actuaries, London, United Kingdom
Department of Internal Medicine and Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands
Department of Family Medicine, Faculty of Medicine, İzmir Democracy University, Izmir, Turkey
Environmental Sustainability and Health Institute, Technological University Dublin, Dublin, Ireland
Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, Catania, Italy
Public Health & Epidemiology, School of Public Health, University College Cork, Cork, Ireland
Department of Health Economics and Social Security, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland
Department of Biostatistics and Medical Informatics, Faculty of Medicine, Kirsehir Ahi Evran University, Kirsehir, Turkey
H&TRC – Health & Technology Research Center, Escola Superior de Tecnologia da Saúde (ESTeSL), Instituto Politécnico de Lisboa, Lisbon, Portugal
Comprehensive Health Research Centre (CHRC), Universidade NOVA de Lisboa, Lisbon, Portugal
Clinical Sciences Institute, School of Medicine, National University of Ireland, Galway, Galway City, Ireland
Andrija Štampar School of Public Health, School of Medicine, University of Zagreb, Zagreb, Croatia
Clinic of Social and Family Medicine, School of Medicine, University of Crete, Crete, Greece
Department of Healthcare, Faculty of Public Health, University of Vlora, Vlora, Albania
Al-Farabi Kazakh National University, Almaty, Kazakhstan
Institute of Maternal, Child Health - IRCCS Burlo Garofolo, Trieste, Italy
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy
Environmental Health and Nutrition Laboratory, Faculty of Medicine, University of Lisbon, Lisbon, Portugal
Laboratory of Social Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece
School of Hygiene & Tropical Medicine, London, United Kingdom
School of Public Health, Physiotherapy and Sport Sciences, University College Dublin, Dublin, Ireland
Department of Geriatric Medicine, Mercy University Hospital, Grenville Place, Cork City, Ireland
Pharmacoepidemiology-Pharmacovigilance, Pharmacy School, School of Sciences and Engineering, University of Nicosia, Nicosia, Cyprus
College of Public Health, University of South Florida, Tampa, FL, United States
Department of Psychology and Pedagogic Science, St Mary’s University, London, United Kingdom
Population Health Department, Luxembourg Institute of Health, Nutrition and Health Research Group, Luxembourg, Luxembourg
Public Health Unit, ACES Grande Porto VIII - Espinho/Gaia, ARS Norte, Lisbon, Portugal
Faculty of Public Health, University of Debrecen, Debrecen, Hungary
Institute of Social Medicine, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Swiss Paraplegic Research, Nottwil, Switzerland
Department of Biology, School of Science and Technology, University of Évora, Évora, Portugal
Comprehensive Health Research Centre (CHRC), University of Évora, Évora, Portugal
Institute of Health and Society (IRSS), Université Catholique de Louvain, Brussels, Belgium
Institute of Public Health of Republic of North Macedonia, Saints Cyril and Methodius University of Skopje, Skopje, North Macedonia
Faculty of Medicine, Saints Cyril and Methodius University of Skopje, Skopje, North Macedonia
Department of Cardiovascular, Endocrine-Metabolic Diseases and Aging, Istituto Superiore Di Sanità, Rome, Italy
Department of Internal Medicine, Adnan Menderes University School of Medicine, Aydin, Turkey
School of Public Health, Università Vita-Salute San Raffaele, Milan, Italy
Faculty of Dentistry Pancevo, University Business Academy in Novi Sad, Pancevo, Serbia
Institute of Public Health of Serbia Dr Milan Jovanović Batut, Belgrade, Serbia
Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy
Unit of Occupational Medicine, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy
Place and Wellbeing Directorate, Public Health Scotland, Glasgow, Scotland, United Kingdom

Department of Public Health
Health Innovation Network
Department of Public Health and Primary Care
Department of Epidemiology and Public Health
Department of Epidemiology and Health Monitoring
Department of Translational Physiology
National Food Institute
Department for Exposure Assessment
Department of Health Statistics
School of Public Health and Community Medicine
Department of Epidemiology and Population Health
National School of Public Health
Medicine School
Department of Public Health
Institute of Public Health
Department of Public Health and Epidemiology
Directorate of Health
Institute for Public Health FB&H
Sports Trauma Research Center
Department of Disease Burden
Department of Health and Functioning
Institute of Neuroscience
Department of Anatomy
Department of Public Health
Department of Health Policy and Management
Department of Nursing
Institute of Public Health
CINTESIS – Center for Health Technology and Services Research
Department of Community Medicine
Department of Sociology
Institute and Faculty of Actuaries
Department of Internal Medicine and Epidemiology
Department of Family Medicine
Environmental Sustainability and Health Institute
Department of General Surgery and Surgical-Medical Specialties
Public Health & Epidemiology
Department of Health Economics and Social Security
Department of Biostatistics and Medical Informatics
H&TRC – Health & Technology Research Center
Comprehensive Health Research Centre (CHRC)
Clinical Sciences Institute
Andrija Štampar School of Public Health
Clinic of Social and Family Medicine
Department of Healthcare
Al-Farabi Kazakh National University
Institute of Maternal
Department of Biomedical and Dental Sciences and Morphofunctional Imaging
Environmental Health and Nutrition Laboratory
Laboratory of Social Medicine
School of Hygiene & Tropical Medicine
School of Public Health
Department of Geriatric Medicine
Pharmacoepidemiology-Pharmacovigilance
College of Public Health
Department of Psychology and Pedagogic Science
Population Health Department
Public Health Unit
Faculty of Public Health
Institute of Social Medicine
Swiss Paraplegic Research
Department of Biology
Comprehensive Health Research Centre (CHRC)
Institute of Health and Society (IRSS)
Institute of Public Health of Republic of North Macedonia
Faculty of Medicine
Department of Cardiovascular
Department of Internal Medicine
School of Public Health
Faculty of Dentistry Pancevo
Institute of Public Health of Serbia Dr Milan Jovanović Batut
Department of Medical and Surgical Sciences
Unit of Occupational Medicine
Place and Wellbeing Directorate

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