Parabacteroides absconsus sp. nov., isolated from feces of a child with atopic dermatitis
Chaplin A.V. Pikina A.P. Shcherbakova V.A. Sokolova S.R. Podoprigora I.V. Das M.S. Koshkin F.A. Ilyina G.A. Vasiliadis I.A. Efimov B.A.
January 2025Springer Science and Business Media Deutschland GmbH
Archives of Microbiology
2025#207Issue 1
An obligate anaerobic, Gram-negative rod-shaped bacterial strain designated AD58T was isolated from the feces of a 3-year-old boy with atopic dermatitis. The closest species is Parabacteroides fecalis with 96.98% 16S rRNA gene identity. The average nucleotide identity value between AD58T and P. fecalis AGMB00274T is 85.0–85.4%. The circular genome sequence is 3.77 Mbp long with 43.5 mol% G + C content. The strain AD58T grows at 32–42 °C, its pH range for growth is 6.0–7.5. No growth is observed in the presence of 1% or higher NaCl concentrations. The major fatty acids are anteiso-C15: 0, iso-C15: 0, and summed feature 11 (iso-C17: 0 3–OH and/or C18: 2 DMA), and the predominant respiratory quinone is MK-9. Conditioned media from AD58T increased expression of IL-8 but decreased expression of TLR-4 in HT29 cells. Based on the described properties, we propose AD58T as the type strain of Parabacteroides absconsus sp. nov. (= VKM B-3630T = JCM 35468T).
Atopic dermatitis , Human gut microbiota , Novel species , Parabacteroides , Tannerellaceae
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Pirogov Russian National Research Medical University, Moscow, Russian Federation
Skryabin Institute of Biochemistry and Physiology of Microorganisms, Federal Research Center “Pushchino Scientific Center for Biological Research, Russian Academy of Sciences”, Pushchino, Russian Federation
Peoples’ Friendship, University of Russia, Moscow, Russian Federation
LLP “Genomed”, Almaty, Kazakhstan
Pirogov Russian National Research Medical University
Skryabin Institute of Biochemistry and Physiology of Microorganisms
Peoples’ Friendship
LLP “Genomed”
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