Salvia lanigera Poiret Extracts: Study of the Phytochemical Profiling via GC–MS and HPLC–DAD and Bioactivity with ADME Analysis
Chahna R. Bendif H. Bouzana A. Derbak L. Haouame I. Çam D. Öztürk M. Rebbas K. Ali M.A.M. Bensouıci C. Boufahja F. Garzoli S.
October 2025Springer
Food Analytical Methods
2025#18Issue 102258 - 2276 pp.
This investigation evaluated the chemical composition and the biological activities of the ethanol and petroleum ether extracts of Salvia lanigera Poiret from the M’sila region, Algeria. Phytochemical analysis identified 17 compounds in the ethanol extract (HPLC–DAD), with cynarin, ellagic acid, and rutin as major components. Petroleum ether extract (GC–MS) revealed 16 compounds, predominantly palmitic acid and stearic acid. Antioxidant activity was assessed using four assays: the ethanol extract showed significant activity in the phenanthroline assay (1.94 ± 0.18 μg/mL), and SNP assay (124.78 ± 0.59 μg/mL), compared to the BHA standard. Both extracts demonstrated antibacterial and antifungal effects, with inhibition zones of 10–13 mm and MIC values ranging from 0.78 to 3.125 mg/mL against tested strains. Enzymatic assays revealed α-glucosidase inhibition by the ethanol extract (IC50 = 27.07 ± 0.78 μg/mL), while α-amylase inhibition was lower (ethanol: 429.85 ± 1.43 μg/mL; petroleum ether: 520.31 ± 1.63 μg/mL). Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition were minimal (IC50 > 200 μg/mL for AChE; ethanol: 365.84 ± 5.48 μg/mL, petroleum ether: 636.13 ± 4.49 μg/mL for BChE). Urease inhibition was notable for the ethanol extract (54.88%) and comparable for the petroleum ether extract (52.00%). These findings highlight the potential of S. lanigera extracts as sources of bioactive compounds with antioxidant, antimicrobial, and enzymatic inhibitory properties, warranting further exploration for therapeutic applications.
Antibacterial activity , Antifungal activity , Antioxidant activity , Enzymatic inhibitory activity , GC–MS , HPLC–DAD , Salvia lanigera Poiret
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Laboratory of Plant Biology and Environment “Medicinal plants” Axis, Department of Biology, Faculty of Sciences, Badji Mokhtar University, B.P 12 Annaba, Annaba, 23000, Algeria
Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia
Laboratory of Interactions, Biodiversity, Ecosystems and Biotechnology, Department of Nature and Life Sciences, Faculty of Sciences, University 20 August 1955 Skikda, Skikda, 21000, Algeria
Department of Natural and Life Sciences, Faculty of Sciences, University of M’sila, University Pole, Road Bordj Bou Arreiridj, M’sila, 28000, Algeria
Department of Chemistry, Faculty of Sciences, Muğla Sıtkı Koçman University, Muğla, 48121, Turkey
Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
National Center of Biotechnology Research, Constantine, 25000, Algeria
Department of Chemistry and Technologies of Drug, Sapienza University, P. Le Aldo Moro, 5, Rome, 00185, Italy
Laboratory of Plant Biology and Environment “Medicinal plants” Axis
Biology Department
Laboratory of Interactions
Department of Natural and Life Sciences
Department of Chemistry
Faculty of Chemistry and Chemical Technology
National Center of Biotechnology Research
Department of Chemistry and Technologies of Drug
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