Therapeutic perspective of thymoquinone: A mechanistic treatise
Butt M.S. Imran M. Imran A. Arshad M.S. Saeed F. Gondal T.A. Shariati M.A. Gilani S.A. Tufail T. Ahmad I. Rind N.A. Mahomoodally M.F. Islam S. Mehmood Z.
March 2021John Wiley and Sons Inc
Food Science and Nutrition
2021#9Issue 31792 - 1809 pp.
The higher utilization of fruits and vegetables is well known to cure human maladies due to the presence of bioactive components. Among these compounds, thymoquinone, a monoterpene and significant constituent in the essential oil of Nigella sativa L., has attained attention by the researchers due to their pharmacologies perspectives such as prevention from cancer, antidiabetic and antiobesity, prevention from oxidative stress and cardioprotective disorder. Thymoquinone has been found to work as anticancer agent against different human and animal cancer stages including propagation, migration, and invasion. Thymoquinone as phytochemical also downregulated the Rac1 expression, mediated the miR-34a upregulation, and increased the levels of miR-34a through p53, as well as also regulated the pro- and antiapoptotic genes and decreased the phosphorylation of NF-κB and IKKα/β. In addition, thymoquinone also lowered the metastasis and ERK1/2 and PI3K activities. The present review article has been piled by adapting narrative review method and highlights the diverse aspects of thymoquinone such as hepatoprotective, anti-inflammatory, and antiaging through various pathways, and further utilization of this compound in diet has been proven effective against different types of cancers.
anticancer , antioxidant potential , cardioprotective disorder , phytochemical , thymoquinone
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Faculty of Food, Nutrition & Home Sciences, National Institute of Food Science and Technology, UAF, Faisalabad, Pakistan
Faculty of Allied Health Sciences, University Institute of Diet and Nutritional Sciences, The University of Lahore, Lahore, Pakistan
Department of Food Science, Institute of Home and Food Sciences, Government College University, Faisalabad, Pakistan
School of Exercise and Nutrition, Faculty of Health, Deakin University, Burwood, VIC, Australia
Food Engineering Department, Shakarim State University of Semey, Semey, Kazakhstan
Department of Dairy Technology, University of Veterinary and Animal Sciences, Lahore, Pakistan
Department of molecular Biology and Genetics, Shaheed Benazir Bhutto University, Shaheed Benazirabad, Pakistan
Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit, Mauritius
Institute of Nutrition and Food Science, University of Dhaka, Dhaka, Bangladesh
School of life Sciences, Forman Christian College (A Chartered University), Lahore, Pakistan
Faculty of Food
Faculty of Allied Health Sciences
Department of Food Science
School of Exercise and Nutrition
Food Engineering Department
Department of Dairy Technology
Department of molecular Biology and Genetics
Department of Health Sciences
Institute of Nutrition and Food Science
School of life Sciences
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