The effects of thymoquinone on pancreatic cancer: Evidence from preclinical studies
Butnariu M. Quispe C. Herrera-Bravo J. Helon P. Kukula-Koch W. López V. Les F. Vergara C.V. Alarcón-Zapata P. Alarcón-Zapata B. Martorell M. Pentea M. Dragunescu A.A. Samfira I. Yessimsiitova Z. Daştan S.D. Castillo C.M.S. Roberts T.H. Sharifi-Rad J. Koch W. Cho W.C.
September 2022Elsevier Masson s.r.l.
Biomedicine and Pharmacotherapy
2022#153
Thymoquinone (TQ) is a secondary metabolite found in abundance in very few plant species including Nigella sativa L., Monarda fistulosa L., Thymus vulgaris L. and Satureja montana L. Preclinical pharmacological studies have shown that TQ has many biological activities, such as anti-inflammatory, antioxidant and anticancer. Both in vivo and in vitro experiments have shown that TQ acts as an antitumor agent by altering cell cycle progression, inhibiting cell proliferation, stimulating apoptosis, inhibiting angiogenesis, reducing metastasis and affecting autophagy. In this comprehensive study, the evidence on the pharmacological potential of TQ on pancreatic cancer is reviewed. The positive results of preclinical studies support the view that TQ can be considered as an additional therapeutic agent against pancreatic cancer. The possibilities of success for this compound in human medicine should be further explored through clinical trials.
Apoptosis , Chemopreventive/anticancer agent , Molecular mechanisms , Pancreatic cancer , Signaling pathways , Thymoquinone
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Banats University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timisoara, Romania
Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, Iquique, 1110939, Chile
Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Chile
Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco, 4811230, Chile
Branch in Sandomierz, Jan Kochanowski University of Kielce, Schinzla 13a Str., 27-600, Sandomierz, Poland
Department of Pharmacognosy with Medicinal Plants Garden, Medical University of Lublin, 1 Chodźki Str, Lublin, 20-093, Poland
Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, Zaragoza, Villanueva de Gállego, 50830, Spain
Instituto Agroalimentario de Aragón-IA2 (CITA-Universidad de Zaragoza), Zaragoza, 50059, Spain
Centro de Investigación de Estudios Avanzados del Maule, Vicerrectoría de Investigación y Postgrado, Universidad Católica del Maule, Chile
Clinical Biochemistry and Immunology Department, Faculty of Pharmacy, University of Concepción, VIII – Bio Bio Region, Concepción, Chile
Facultad de Medicina Veterinaria, Universidad San Sebastián, Lientur 1457, Concepción, 4080871, Chile
Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción, 4070386, Chile
Universidad de Concepción, Unidad de Desarrollo Tecnológico, UDT, Concepción, 4070386, Chile
Department of Biodiversity and Bioresource, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department of Biology, Faculty of Science, Sivas Cumhuriyet University, Sivas, 58140, Turkey
Beekeeping Development Application and Research Center, Sivas Cumhuriyet University, Sivas, 58140, Turkey
Facultad de Medicina, Universidad del Azuay, Cuenca, 14-008, Ecuador
Plant Breeding Institute, Sydney Institute of Agriculture, University of Sydney, 2006, NSW, Australia
Department of Food and Nutrition, Medical University of Lublin, 4a Chodźki Str, Lublin, 20-093, Poland
Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
Banats University of Agricultural Sciences and Veterinary Medicine “King Michael I of Romania” from Timisoara
Facultad de Ciencias de la Salud
Departamento de Ciencias Básicas
Center of Molecular Biology and Pharmacogenetics
Branch in Sandomierz
Department of Pharmacognosy with Medicinal Plants Garden
Department of Pharmacy
Instituto Agroalimentario de Aragón-IA2 (CITA-Universidad de Zaragoza)
Centro de Investigación de Estudios Avanzados del Maule
Clinical Biochemistry and Immunology Department
Facultad de Medicina Veterinaria
Department of Nutrition and Dietetics
Universidad de Concepción
Department of Biodiversity and Bioresource
Department of Biology
Beekeeping Development Application and Research Center
Facultad de Medicina
Plant Breeding Institute
Department of Food and Nutrition
Department of Clinical Oncology
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