Regulation of mhc i molecules in glioblastoma cells and the sensitizing of nk cells
Burster T. Gärtner F. Bulach C. Zhanapiya A. Gihring A. Knippschild U.
March 2021MDPI AG
Pharmaceuticals
2021#14Issue 3
Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be by-passed by tumors through altered and/or reduced expression levels of major histocompatibility complex class I (MHC I) molecules. Natural killer (NK) cells can eliminate tumor cells in a MHC I antigen presentation‐independent manner by an array of activating and inhibitory receptors, which are promising candidates for immunotherapy. Here we summarize the latest findings in recogniz-ing and regulating MHC I molecules that affect NK cell surveillance of glioblastoma cells.
Cathepsin G , Immunotherapy , MHC , NK cells , Proteases
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Department of Biology, School of Sciences and Humanities, Nazarbayev University, Kabanbay Batyr Ave. 53, Nur‐Sultan, 010000, Kazakhstan
Surgery Center, Department of General and Visceral Surgery, Ulm University Hospital, Albert‐Einstein‐Allee 23, Ulm, 89081, Germany
Department of Biology
Surgery Center
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026