Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation
Burster T. Mustafa Z. Myrzakhmetova D. Zhanapiya A. Zimecki M.
15 November 2021Frontiers Media S.A.
Frontiers in Chemistry
2021#9
During inflammation neutrophils become activated and segregate neutrophil serine proteases (NSPs) to the surrounding environment in order to support a natural immune defense. However, an excess of proteolytic activity of NSPs can cause many complications, such as cardiovascular diseases and chronic inflammatory disorders, which will be elucidated on a biochemical and immunological level. The application of selective serine protease inhibitors is the logical consequence in the management of the indicated comorbidities and will be summarized in this briefing. Copyright
cathepsin G , COVID-19 , neutrophil elastase , proteinase 3 , SARS-CoV-2 , serine protease inhibitors , serine proteases , thrombosis
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Department of Biology, School of Sciences and Humanities, Nazarbayev University, Nur-Sultan, Kazakhstan
Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
Department of Biology
Hirszfeld Institute of Immunology and Experimental Therapy
10 лет помогаем публиковать статьи Международный издатель
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