Synthesis and study of a novel supramolecular host–guest complex based on cucurbit[6]uril and 1,4-bis(2-hydroxyethyl)piperazine dihydrochloride

Burkhanbayeva T. Guslyakov A.N. Tarikhov F.F. Pavlov D.I. Erkasov R.S. Bakibaev A.A. Potapov A.S. Yanovsky V.A. Malkov V.S.
March 2024 Elsevier B.V.

Journal of Saudi Chemical Society
2024 #28 Issue 2

A novel supramolecular complex C₄₄H₇₁Cl₂N₂₆O₂₂ (CB[6]@Pipa·2HCl) of the “host-guest” type has been synthesized. It is based on cucurbit[6]uril (CB[6]) with dihydrochloride 1,4-bis(2-hydroxyethyl)piperazine (Pipa·2HCl) localized within the portals of the macrocycle. Based on 1H NMR and X-ray crystallography, the host–guest ratio in the complex under the specified conditions was determined to be 1:1. Further evidence of complex formation was observed through IR spectroscopy, where a shift in the absorption band of carbonyl vibrational frequencies of cucurbit[6]uril by 36 cm⁻¹ towards the longer wavelength region was detected in CB[6]@Pipa·2HCl compared to the original CB[6]. TGA/DSC analysis results indicated an increase in thermal stability by 55 °C for the obtained CB[6]@Pipa·2HCl complex compared to the initial 1,4-bis(2-hydroxyethyl)piperazine dihydrochloride. The structure of the synthesized CB[6]@Pipa·2HCl complex was confirmed using single-crystal XRD.

1,4-bis(2-hydroxyethyl)piperazine dihydrochloride , Cucurbit[6]uril , Host–guest complex , Single Crystal X-ray Diffraction , Structure , Supramolecule

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Department of Chemistry, Faculty of Science, L. N. Gumilyov, Eurasian National University, Astana, 010008, Kazakhstan
Department of Chemistry, National Research Tomsk State University, Tomsk, 634050, Russian Federation
Department of Chemistry, Faculty of Science, Nazarbayev University, Astana, 010000, Kazakhstan
Nikolaev Institute of Inorganic Chemistry, Novosibirsk, 630090, Russian Federation

Department of Chemistry
Department of Chemistry
Department of Chemistry
Nikolaev Institute of Inorganic Chemistry

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