The Influence of the Associated Inactivated Vaccine Against Infectious Rhinotracheitis and Bovine Viral Diarrhea on the Formation and Duration of Colostral Immunity in Kazakh Whiteheaded Calves

Bulatov Y. Kurmasheva A. Amanova Z. Abitaev R. Sametova Z. Kyrgyzbayeva A. Kondybaeva Z. Turyskeldi S. Ussembay A. Toktyrova D. Mazbayeva D. Shayakhmetov Y. Kerimbayev A. Khussainov D. Wentao M. Rsaliyev A. Abduraimov Y.
April 2025 Multidisciplinary Digital Publishing Institute (MDPI)

Vaccines
2025 #13 Issue 4

Objectives: This article presents a study evaluating the antibody levels against infectious bovine rhinotracheitis (IBR) and bovine viral diarrhea (BVD) in Kazakh Whiteheaded calves born to dams immunized with an experimental inactivated combined vaccine against these infections. The vaccine formulation includes the strains “R-93” (IBR) and “Oregon C₂₄V” (BVD), which are preserved in the microorganism collection of the Research Institute for Biological Safety Problems. Methods: To assess the immune response in newborn calves, blood serum samples were collected before the first intake of colostrum, followed by weekly sampling for 28 weeks post-birth. The antibody response was determined using a virus neutralization assay on MDBK cell cultures and lamb testicle cell cultures. Results: The results demonstrated that the protective antibody level against the IBR virus (≥2 log₂) persisted for up to 25 weeks, while the protective level against the BVD virus (≥3 log₂) remained for 23 weeks. Based on these findings, the vaccine was deemed safe, as it did not induce abortions or clinical manifestations of the diseases. The overall duration of the colostral immunity in calves against the IBR and BVD viruses reached 23 weeks. Conclusions: Therefore, it is recommended that Kazakh Whiteheaded calves be vaccinated with the associated inactivated vaccine against infectious bovine rhinotracheitis and bovine viral diarrhea no earlier than 23 weeks of age.

bovine viral diarrhea , colostral immunity , infectious bovine rhinotracheitis , pregnant cows

Text of the article Перейти на текст статьи

Research Institute for Biological Safety Problems, National Holding “QazBioPharm”, Guardeyskiy, 080409, Kazakhstan
Department of Veterinary and Zooengineering, Kazakh National Agrarian Research University, Almaty, 050010, Kazakhstan
College of Veterinary Medicine, Northwest Agriculture and Forestry University, Xianyang, 712100, China
National Holding “QazBioPharm”, Astana, 010000, Kazakhstan

Research Institute for Biological Safety Problems
Department of Veterinary and Zooengineering
College of Veterinary Medicine
National Holding “QazBioPharm”

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026