Predictive accuracy of genetic variants for eye color in a Kazakh population using the IrisPlex system
Bukayev A. Gorin I. Aidarov B. Darmenov A. Balanovska E. Zhabagin M.
December 2024BioMed Central Ltd
BMC Research Notes
2024#17Issue 1
Objective: This study assesses the accuracy of the IrisPlex system, a genetic eye color prediction tool for forensic analysis, in the Kazakh population. The study compares previously published genotypes of 515 Kazakh individuals from varied geographical and ethnohistorical contexts with phenotypic data on their eye color, introduced for the first time in this research. Results: The IrisPlex panel’s effectiveness in predicting eye color in the Kazakh population was validated. It exhibited slightly lower accuracy than in Western European populations but was higher than in Siberian populations. The sensitivity was notably high for brown-eyed individuals (0.99), but further research is needed for blue and intermediate eye colors. This study establishes IrisPlex as a useful predictive tool in the Kazakh population and provides a basis for future investigations into the genetic basis of phenotypic variations in this diverse population.
Eye color , Forensic genetics, IrisPlex System , Kazakh population , Microarray , SNP Genotyping
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National Center for Biotechnology, Astana, 010000, Kazakhstan
Research Centre for Medical Genetics, Moscow, 115522, Russian Federation
Karaganda Academy of the Ministry of Internal Affairs of the Republic of Kazakhstan named after Barimbek Beisenov, Karaganda, 100000, Kazakhstan
National Center for Biotechnology
Research Centre for Medical Genetics
Karaganda Academy of the Ministry of Internal Affairs of the Republic of Kazakhstan named after Barimbek Beisenov
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