The epidemiology of myasthenia gravis
Bubuioc A.-M. Kudebayeva A. Turuspekova S. Lisnic V. Leone M.A.
2021Carol Davila University Press
Journal of Medicine and Life
2021#14Issue 17 - 16 pp.
Neuromuscular junction (NMJ) disorders include several dysfunctions that ultimately lead to muscle weakness. Myasthenia gravis (MG) is the most prevalent NMJ disorder with a highly polymorphic clinical presentation and many different faces. Being an autoimmune disease, MG correlates with the presence of detectable antibodies directed against the acetylcholine receptor, muscle-specific kinase, lipoprotein-related protein 4, agrin, titin, and ryanodine in the postsynaptic membrane at the NMJ. MG has become a prototype serving to understand both autoimmunity and the function of the NMJ better. The aim of this review is to synthesize some of the epidemiological data avail-able. Epidemiological data regarding MG are important for postulating hypotheses regarding its etiology and facilitating the description of MG subtypes. Thus, adequate documentation through broad databases is essential. The incidence and prevalence of MG reported around the globe have been rising steadily and consistently over the past decades. Ethnic aspects, gender-related differences, and environmental risk factors have been described, implying that these might contribute to a specific phenotype, further suggesting that MG may be considered an umbrella term that covers several clinical entities.
autoimmunity , epidemiology , incidence , myasthenia gravis , prevalence
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Department of Neurology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Moldova
Department of Neurology, Kazakh Medical University of Continuing Education, Almaty, Kazakhstan
Department of Nervous Diseases with course of Neurosurgery, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Neurology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Department of Neurology
Department of Neurology
Department of Nervous Diseases with course of Neurosurgery
Neurology Unit
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