Prevalence of Crimean-Congo Hemorrhagic Fever Virus among Livestock and Ticks in Zhambyl Region, Kazakhstan, 2017
Bryant-Genevier J. Bumburidi Y. Kazazian L. Seffren V. Head J.R. Berezovskiy D. Zhakipbayeva B. Salyer S.J. Knust B. Klena J.D. Chiang C.-F. Mirzabekova G. Rakhimov K. Koekeev J. Kartabayev K. Mamadaliyev S. Guerra M. Blanton C. Shoemaker T. Singer D. Moffett D.B.
May 2022American Society of Tropical Medicine and Hygiene
American Journal of Tropical Medicine and Hygiene
2022#106Issue 51478 - 1485 pp.
Crimean-Congo hemorrhagic fever (CCHF) is a highly fatal zoonotic disease endemic to Kazakhstan. Previous work estimated the seroprevalence of CCHF virus (CCHFV) among livestock owners in the Zhambyl region of southern Kazakhstan at 1.2%. To estimate CCHFV seroprevalence among cattle and sheep, we selected 15 villages with known history of CCHFV circulation (endemic) and 15 villages without known circulation (nonendemic) by cluster sampling with probability proportional to livestock population size. We collected whole blood samples from 521 sheep and 454 cattle from randomly selected households within each village and collected ticks found on the animals. We tested livestock blood for CCHFV-specific IgG antibodies by ELISA; ticks were screened for CCHFV RNA by real-time reverse transcription polymerase chain reaction and CCHFV antigen by antigen-capture ELISA. We administered questionnaires covering animal demographics and livestock herd characteristics to an adult in each selected household. Overall weighted seroprevalence was 5.7% (95% CI: 3.1, 10.3) among sheep and 22.5% (95% CI: 15.8, 31.2) among cattle. CCHFV-positive tick pools were found on two sheep (2.4%, 95% CI: 0.6, 9.5) and three cattle (3.8%, 95% CI: 1.2, 11.5); three CCHFV-positive tick pools were found in nonendemic villages. Endemic villages reported higher seroprevalence among sheep (15.5% versus 2.8%, P, 0.001) but not cattle (25.9% versus 20.1%, P 5 0.42). Findings suggest that the current village classification scheme may not reflect the geographic distribution of CCHFV in Zhambyl and underscore that public health measures must address the risk of CCHF even in areas without a known history of circulation. Copyright
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U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States
Epidemic Intelligence Service, Center for Surveillance, Epidemiology and Laboratory Services, U.S. Centers for Disease Control and Prevention, Atlanta, GA, United States
U.S. Centers for Disease Control and Prevention – Central Asia Office, Almaty, Kazakhstan
Association of Schools and Programs of Public Health, Atlanta, GA, United States
Zhambyl Oblast Department of Health, MoH, Taraz, Kazakhstan
Zhambyl Oblast Department for Quality Control and Safety of Goods and Services, MoH, Taraz, Kazakhstan
Zhambyl Oblast Veterinary Inspection, MoA, Taraz, Kazakhstan
Zhambyl Oblast Veterinary Department of Oblast Administration, Taraz, Kazakhstan
Central Reference Laboratory, Branch of NRCV, MoES, Almaty, Kazakhstan
U.S. Centers for Disease Control and Prevention
Epidemic Intelligence Service
U.S. Centers for Disease Control and Prevention – Central Asia Office
Association of Schools and Programs of Public Health
Zhambyl Oblast Department of Health
Zhambyl Oblast Department for Quality Control and Safety of Goods and Services
Zhambyl Oblast Veterinary Inspection
Zhambyl Oblast Veterinary Department of Oblast Administration
Central Reference Laboratory
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