Aldehyde-functional thermoresponsive diblock copolymer worm gels exhibit strong mucoadhesion
Brotherton E.E. Neal T.J. Kaldybekov D.B. Smallridge M.J. Khutoryanskiy V. Armes S.P.
26 May 2022Royal Society of Chemistry
Chemical Science
2022#13Issue 236888 - 6898 pp.
A series of thermoresponsive diblock copolymer worm gels is prepared via reversible addition-fragmentation chain transfer (RAFT) aqueous dispersion polymerization of 2-hydroxypropyl methacrylate using a water-soluble methacrylic precursor bearing pendent cis-diol groups. Selective oxidation using an aqueous solution of sodium periodate affords the corresponding aldehyde-functional worm gels. The aldehyde groups are located within the steric stabilizer chains and the aldehyde content can be adjusted by varying the periodate/cis-diol molar ratio. These aldehyde-functional worm gels are evaluated in terms of their mucoadhesion performance with the aid of a fluorescence microscopy-based assay. Using porcine urinary bladder mucosa as a model substrate, we demonstrate that these worm gels offer a comparable degree of mucoadhesion to that afforded by chitosan, which is widely regarded to be a ‘gold standard’ positive control in this context. The optimum degree of aldehyde functionality is approximately 30%: lower degrees of functionalization lead to weaker mucoadhesion, whereas higher values compromise the desirable thermoresponsive behavior of these worm gels.
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Dainton Building, Department of Chemistry, University of Sheffield, Brook Hill, South Yorkshire, Sheffield, S3 7HF, United Kingdom
School of Pharmacy, University of Reading, Whiteknights, PO Box 224, Reading, Berkshire, RG6 6DX, United Kingdom
Department of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
GEO Specialty Chemicals, Hythe, Hampshire SO45 3ZG, Southampton, United Kingdom
Dainton Building
School of Pharmacy
Department of Chemistry and Chemical Technology
GEO Specialty Chemicals
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