Prognostic criteria for preterm birth in pregnant women infected with COVID-19 in the third trimester: a case-control study

Bozhbanbayeva N.S. Urstemova K.K. Tarabayeva A.S. Bitanova E.Zh. Abilbayeva A.A. Suleimenova I.E.
2024 Dynasty Publishing House

Voprosy Ginekologii, Akusherstva i Perinatologii
2024 #23 Issue 3 39 - 47 pp.

Objective. To determine the prognostic criteria for preterm birth due to SARS-CoV-2 infection. Patients and methods. A retrospective case-control study was conducted. Data on 1041 pregnant women infected with COVID-19 in the third trimester between April 2020 and December 2022 were analyzed. The Chi-square test was used to compare qualitative variables. The binary logistic regression model was used to identify factors associated with preterm birth in women infected with COVID-19. The ROC curve analysis for logistic regression was performed to assess the prognostic significance of the combination of the identified risk factors for preterm birth in women with COVID-19. Results. Regression analysis showed a positive correlation between pre-eclampsia (OR = 2.927, 95% CI: 1.328–6.452, p = 0.008), chronic infections (OR = 3.751, 95% CI: 1.931–7.287, p < 0. 0001), absence of therapy with low-molecular-weight heparin (OR = 2.481, 95% CI: 1.302–4.729, p = 0.006) and acetylsalicylic acid (OR = 1.945, 95% CI: 1.051–3.597, p = 0.034) and preterm birth. The ROC curve analysis for separate factors such as the absence of therapy with low-molecular-weight heparin and acetylsalicylic acid, age, aggravated obstetric history, pre-eclampsia and chronic infections did not show a high predictive value. The area under the curve (AUC) was less than 0.6 (0.395; 0.445; 0.589; 0.557; 0.558; 0.575, respectively). At the same time, the combination of absent anticoagulant therapy and each factor separately had a significantly higher prognostic value (AUC above 0.6 in all cases). Conclusion. The risk of preterm birth in pre-eclampsia and the presence of chronic infections in pregnant women infected with COVID-19 in the third trimester is significantly higher in the absence of anticoagulant therapy.

anticoagulants , COVID-19 , pregnancy , preterm birth , prognostic criteria

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S.D.Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Scientific Center of Pediatrics and Pediatric Surgery, Almaty, Kazakhstan

S.D.Asfendiyarov Kazakh National Medical University
Scientific Center of Pediatrics and Pediatric Surgery

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