Controlled Synthesis of Small Water-Soluble Hybrid Gold Nanoparticles: An Optimized Strategy for Stable Nano-Dispersion and Towards Cellular Uptake
Bouyon Yenda T. Jiguet-Jiglaire C. Khichane I. Gobert Q. Prabhakaran R. De Nonneville A. Djenizian T. Salas S. Dallemer F.
22 March 2022Frontiers Media S.A.
Frontiers in Mechanical Engineering
2022#8
The development of effective drug delivery systems is one of the major challenges in the fight against cancer. Gold nanoparticles could effectively harness cancer therapies by improving their potency while reducing toxic side effects. In this work, we describe a high-yield one-step synthesis of small water-soluble gold nanoparticles (AuNPs). Efficient purification was monitored, and discrete structure was fully characterized by combining molecular analytical technics (UV-visible and NMR spectroscopies) and solid-state analyses (thermal gravimetric analysis and transmission electron microscopy). These AuNPs have good dispersibility in various biocompatible media and can be used without any additives. Preliminary study with in vitro treatment of IB115 human cancer cells showed massive cellular uptake associated to moderate intrinsic cytotoxicity. The high control of the synthesis and the small size of these AuNPs are offering fine surface properties control, crucial for challenging biological nano-dispersion issues. Thus, limitation of the agglomeration of nanoparticles and improvement of interaction with the surface of cell should open new leads for vectorization of drugs or imaging probes for diagnosis. Copyright
cellular uptake , chemical characterizations , cytotoxicity , hybrid gold nanoparticles , nano-dispersion , para-hydroxybenzenethiol
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MADIREL AMU, CNRS UMR7246 Aix Marseille Université, Marseille, France
Institut of Neurophysiology, INP AMU-CNRS Aix Marseille Université, Marseille, France
Department of Anatomopathology, CHU Timone, AP-HM Aix Marseille Université, Marseille, France
Department of Chemistry, Bharathiar University, Coimbatore, India
Medical Oncology Unit, CHU Timone Adulte, AP-HM Aix Marseille Université, Marseille, France
Center of Microelectronics in Provence, Flexible Electronics Department, Mines Saint-Etienne, Gardanne, France
Center of Physical-Chemical Methods of Research and Analysis, Al-Farabi Kazakh National University, Almaty, Kazakhstan
MADIREL AMU
Institut of Neurophysiology
Department of Anatomopathology
Department of Chemistry
Medical Oncology Unit
Center of Microelectronics in Provence
Center of Physical-Chemical Methods of Research and Analysis
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