Therapeutic Repurposing of Antiviral Drugs Available for COVID-19 Therapy: A Mini Review
Bounoua N. Al Azzam K.M. Aboul-Enein H.Y. Rebizi M.N. Negim E.-S.
August 2022Asian Publication Corporation
Asian Journal of Chemistry
2022#34Issue 81993 - 1996 pp.
The impact of repurposing drugs that now in vitro inhibit significant chronic respiratory illness corona virus type 2 was indeed underestimated or ignored during the early phases of the COVID-19 virus. Recent clinical data, however, suggest that remdesivir and favipiravir may hasten to heal, but lopinavir/ritonavir had minimal impact on very ill patients. The interferon appears to be the primary impact of triple therapy with ribavirin, lopinavir and interferon-1b. The role of hydroxychloroquine, marketed as Plaquenil® or chloroquine, marketed as Aralen®, in the treatment and prevention of COVID-19 is presently unknown due to the small sample size research. Anti-cytokine drugs may not benefit persons with mild disease or severe illness. Traditional Chinese medicine (TCM) is commonly used for COVID-19 patients in China and has antiviral and immunomodulatory effects on SARS-CoV-2. This review outlines existing COVID-19 therapeutic options and advocates for clinical trials for children, persons with mild disease and those in the early stages of COVID-19.
Antiviral agents , Corona virus , Covid-19 disease , Covid-19 therapy , Drugs
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Department of Exact Sciences, Normal Higher School of Bechar, Algeria, Laboratory of Chemical and Environmental Science (LCSE), Bechar, Algeria
Department of Pharmaceutical Sciences, Pharmacological and Diagnostic Research Center (PDRC), Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, Jordan
Department of Medicinal and Pharmaceutical Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Cairo, 12622, Egypt
Organic Chemistry and Natural Substances Laboratory, Zian Achor University, Djelfa, Algeria
School of Petroleum Engineering, Satbayev University, 22 Satpayev Street, Almaty, 050013, Kazakhstan
Department of Exact Sciences
Department of Pharmaceutical Sciences
Department of Medicinal and Pharmaceutical Chemistry
Organic Chemistry and Natural Substances Laboratory
School of Petroleum Engineering
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