State-of-the-Art Applications of Cyclodextrin Nanocomposite in Analytical Chemistry: a Mini Review
Bounoua N. Al Azzam K.M. Aboul-Enein H.Y. Rahou I. Rebizi M.N. Negim E.-S.
August 2025Springer
Pharmaceutical Chemistry Journal
2025#59Issue 5590 - 597 pp.
The industry is searching for novel materials that can respond to particular applications that can only be met by advanced materials. In this regard, nanoparticles and nanocomposites have opened a fascinating approach for creating certain qualities that may be modified according to need. Cyclodextrins (CDs) are cyclic oligosaccharides that comprise glucopyranose subunits that are alpha-(1→4)-linked, and produce inclusion complexes (host-guest complexes) containing several solids. The colloidal nanoparticle is a flexible medication delivery method. Weakly water-soluble drugs are more readily soluble thanks to the CDs, and they may enhance several drug-related characteristics, such as drug loading in nano-systems, site-specific/targeted drug delivery, stability, absorption, solubility profile, bioavailability, controlled release, safety, and efficacy. Presently, polymers, have acquired specificity, thermal stability, mechanical stability, solvent resistance, and biodegradability thanks to the addition of CDs to the nanocomposites. Several CDs have become important candidates in separation sciences; therefore, their constructions and intercalation processes have been investigated in depth. The objective of the current mini-review is to use CDs to address their applications in drug delivery, mycotoxin analysis, additives to mobile phase in HPLC, additives in background electrolyte (BGE) in capillary electrophoresis, and molecular recognition applications of CD-nanocomposites, as well as to highlight its difficulties with the composition of nanoparticles (NPs) and enhance their performance.
analytical applications , chromatography , cyclodextrins , nanocomposites , separation
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Department of Exact Sciences, Laboratory of the innovation sponsorship and the emerging institution for graduates of higher education of sustainable development and dealing with emerging conditions, Normal Higher School of Bechar, Bechar, 8000, Algeria
Laboratory of Chemical and Environmental Science (LCSE), Bechar, 8000, Algeria
Department of Chemistry, School of Science, The University of Jordan, Amman, 11942, Jordan
Department of Medicinal and Pharmaceutical Chemistry, Pharmaceutical and Drug Industries Research Division, National Research Centre, Cairo, 12622, Egypt
University of Tahri Mohamed Bechar, Bechar, 08000, Algeria
Organic Chemistry and Natural Substances Laboratory, Zian Achor University, Djelfa, Algeria
School of Chemical Engineering, Kazakh British Technical University, 106 Walikhanov Street, Almaty, 050010, Kazakhstan
School of Petroleum Engineering, Satbayev University, 22 Satpayev Street, Almaty, 050013, Kazakhstan
Department of Exact Sciences
Laboratory of Chemical and Environmental Science (LCSE)
Department of Chemistry
Department of Medicinal and Pharmaceutical Chemistry
University of Tahri Mohamed Bechar
Organic Chemistry and Natural Substances Laboratory
School of Chemical Engineering
School of Petroleum Engineering
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