Exploring the frontiers of penicillin pharmaceuticals: a comprehensive review of advancements and innovations
Boshkayeva A. Massakbayev A. Sayakova G. Mombekov S. Yussupov R. Arystanova T. Tazhiyeva A. Ibadullayeva G. Pushkarskaya N. Tleubayeva M. Aitzhanova G. Kayupova F. Kozhanova K.
January 2026SPER Publications
Journal of Advanced Pharmacy Education and Research
2026#16Issue 1138 - 148 pp.
Penicillin and its derivatives have remained a cornerstone in combating bacterial infections for decades. However, growing concerns about bacterial resistance and the limitations of conventional penicillin production methods underscore the need for innovative approaches. The aim of this review is to address the challenge of developing penicillin and related compounds by proposing a novel approach to improving the quality of medicines to meet healthcare demand. The discovery and optimization of microbial sources for penicillin production pose potential solutions to the growing demand for novel antibiotics. High-throughput screening techniques, genomics, and bioinformatics tools enable the identification and characterization of novel penicillin-producing microorganisms. The optimization of enzyme production and purification processes further enhances the scalability and cost-effectiveness of penicillin biosynthesis. However, despite significant progress, several gaps persist in large-scale, sustainable penicillin production and effective manufacturing processes. To address these gaps, this review provides a comprehensive overview of recent advancements and emerging trends in the development and manufacturing of penicillin. With an interdisciplinary lens, we point out new approaches, including biocatalysis, green chemistry principles, and advanced processes. Integrating these strategies would develop the next-generation penicillin derivatives with better efficiency, reduced environmental footprint, and enhanced resistance profiles. This extraordinary combination of research identifies current gaps in penicillin drug development and charts a path toward sustainable solutions for future antibiotic needs.
Antibiotics , Computational design , Green manufacturing , Penicillin synthesis , Pharmaceuticals
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Department of Pharmaceutical and Toxicological Chemistry, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Pharmacognosy with Botany course, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Engineering Disciplines and Good Practices, Asfendiyarov Kazakh National Medical University, Kazakhstan
Department of microbiology, virology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Pharmaceutical Disciplines, NpJSC Astana Medical University, Astana, Kazakhstan
Department of Science, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Pharmaceutical Technology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Organization and Management and Economics of Pharmacy and Clinical Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Normal Physiology and Biophysics, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Candidate of Pharmaceutical Science, Kazakh-Russian Medical University, Irgeli village, Karasay district, Almaty, Kazakhstan
Department of Pharmaceutical and Toxicological Chemistry
Department of Pharmacognosy with Botany course
Department of Engineering Disciplines and Good Practices
Department of microbiology
Department of Pharmaceutical Disciplines
Department of Science
Department of Pharmaceutical Technology
Department of Organization and Management and Economics of Pharmacy and Clinical Pharmacy
Department of Normal Physiology and Biophysics
Candidate of Pharmaceutical Science
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026