Gut Enterobacteriaceae and uraemic toxins - Perpetrators for ageing
Boopathi S. Kumar R.M.S. Priya P.S. Haridevamuthu B. Nayak S.P.R.R. Chulenbayeva L. Almagul K. Arockiaraj J.
March 2023Elsevier Inc.
Experimental Gerontology
2023#173
Ageing is a complex process that is associated with changes in the composition and functions of gut microbiota. Reduction of gut commensals is the hallmarks of ageing, which favours the expansion of pathogens even in healthy centenarians. Interestingly, gut Enterobacteriaceae have been found to be increased with age and also consistently observed in the patients with metabolic diseases. Thus, they are associated with all-cause mortality, regardless of genetic origin, lifestyle, and fatality rate. Moreover, Enterobacteriaceae are also implicated in accelerating the ageing process through telomere attrition, cellular senescence, inflammasome activation and impairing the functions of mitochondria. However, acceleration of ageing is likely to be determined by intrinsic interactions between Enterobacteriaceae and other associated gut bacteria. Several studies suggested that Enterobacteriaceae possess genes for the synthesis of uraemic toxins. In addition to intestine, Enterobacteriaceae and their toxic metabolites have also been found in other organs, such as adipose tissue and liver and that are implicated in multiorgan dysfunction and age-related diseases. Therefore, targeting Enterobacteriaceae is a nuance approach for reducing inflammaging and enhancing the longevity of older people. This review is intended to highlight the current knowledge of Enterobacteriaceae-mediated acceleration of ageing process.
Enterobacteriaceae , Gut dysbiosis , Inflammaging , Metabolic diseases , Uraemic toxins
Text of the article Перейти на текст статьи
Department of Biotechnology, College of Science and Humanities, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, Chennai, 603203, India
Department of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, Chennai, 602105, India
Laboratory of Human Microbiome and Longevity, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Nur-Sultan, 010 000, Kazakhstan
Department of Biotechnology
Department of Biotechnology
Laboratory of Human Microbiome and Longevity
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026