Biologically Active Ammonium Isatin-3-acylhydrazones Bearing Long-Chain Alkyl Substituent of Various Structures
Bogdanov A.V. Samorodov A.V. Valiullina Z.A. Akylbekov N.I. Voloshina A.D. Lyubina A.P. Amerkhanova S.K. Saitova A.M. Pashirova T.N. Tsivileva O.M. Mironov V.F.
March 2024Pleiades Publishing
Russian Journal of General Chemistry
2024#94Issue 3539 - 552 pp.
Abstract: New ammonium hydrazones have been synthesized by the reaction of Girard’s reagents T and P with isatin derivatives that contain various alkyl or geranyl substituents in position 1. A pronounced anti-anthropo- and antiphyto-pathogenic effect of resulting compounds has been revealed. The n-octyl and octadiene derivatives have the highest selectivity for resistant strains of Staphylococcus aureus when there is no negative effect on the hemostasis system. The aggregation and adsorption properties of the compounds have been studied using tensiometry, conductometry, and UV spectroscopy. The found values of the critical micelle concentration of amphiphilic ammonium hydrazones are an order of magnitude lower than those of quaternary ammonium salts.
ammonium salts , amphiphiles , biological activity , hydrazones , isatin
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A.E. Arbuzov Institute of Organic and Physical Chemistry, Federal Reseatch Center “Kazan Scientific Center of the Russian Academy of Sciences”, Kazan, 420088, Russian Federation
Bashkir State Medical University, Ufa, 450008, Russian Federation
Laboratory of Engineering Profile “Physical and Chemical Methods of Analysis”, Korkyt Ata Kyzylorda University, Kyzylorda, 120014, Kazakhstan
Institute of Biochemistry and Physiology of Plants and Microorganisms, Saratov Scientific Centre of the Russian Academy of Sciences, Saratov, 410049, Russian Federation
A.E. Arbuzov Institute of Organic and Physical Chemistry
Bashkir State Medical University
Laboratory of Engineering Profile “Physical and Chemical Methods of Analysis”
Institute of Biochemistry and Physiology of Plants and Microorganisms
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