The Gut Microbiota-anxiety Connection: Evidence, Mechanisms, and Therapeutic Strategies
Bjørklund G. Butnariu M. Dadar M. Semenova Y.
2025Bentham Science Publishers
Current Medicinal Chemistry
2025#32Issue 378233 - 8250 pp.
The gut-brain axis (GBA), a bidirectional communication system between the gut and the brain, has emerged as a critical player in mental health. The interest in the connection between anxiety disorders (AD) and the gut microbiota is growing. This paper provides an overview of gut microbiota’s role in dysregulation in anxiety, including alterations in gut microbiota (dysbiosis), leaky gut, metabolic endotoxemia, and the effect of antipsychotic medications. The mechanisms underlying the gut microbiota-anxiety (GMA) connection, such as neurotransmitter production, immune dysregulation, and GBA communication, are discussed. Furthermore, the paper explores gut microbiota-based therapeutic strategies, including probiotics, prebiotics, symbiotics, fecal microbiota transplantation, and dietary interventions, as potential approaches for anxiety management. This research fields clinical implications and future directions are also examined, underscoring that more studies are needed on gut microbiota’s role in anxiety disorders. The conclusion highlights the importance of this ongoing research and the potential for personalized therapeutic interventions, instilling hope and optimism for the future of anxiety management and providing reassurance about the potential for personalized therapeutic interventions in this field. Bentham Science Publishers
antipsychotics , anxiety disorders , dietary interventions , dysbiosis , fecal microbiota transplantation , gut microbiota , Gut-brain axis , leaky gut , metabolic endotoxemia , prebiotics , probiotics , symbiotics
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Council for Nutritional and Environmental Medicine, Mo i Rana, Norway
University of Life Sciences “King Mihai I” from Timisoara, Timis, Romania
CONEM Romania Biotechnology and Environmental Sciences Group, University of Life Sciences “King Mihai I” from Timisoara, Timis, Romania
CONEM International Microbiology Research Group, Paris, France
Department of Surgery, Nazarbayev University School of Medicine, Astana, Kazakhstan
Council for Nutritional and Environmental Medicine
University of Life Sciences “King Mihai I” from Timisoara
CONEM Romania Biotechnology and Environmental Sciences Group
CONEM International Microbiology Research Group
Department of Surgery
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