Iron deficiency in obesity and after bariatric surgery
Bjørklund G. Peana M. Pivina L. Dosa A. Aaseth J. Semenova Y. Chirumbolo S. Medici S. Dadar M. Costea D.-O.
May 2021MDPI AG
Biomolecules
2021#11Issue 5
Iron deficiency (ID) is particularly frequent in obese patients due to increased circulating levels of acute-phase reactant hepcidin and adiposity-associated inflammation. Inflammation in obese subjects is closely related to ID. It induces reduced iron absorption correlated to the inhibition of duodenal ferroportin expression, parallel to the increased concentrations of hepcidin. Obese subjects often get decreased inflammatory response after bariatric surgery, accompanied by decreased serum hepcidin and therefore improved iron absorption. Bariatric surgery can induce the mitigation or resolution of obesity-associated complications, such as hypertension, insulin resistance, diabetes mellitus, and hyperlipidemia, adjusting many parameters in the metabolism. However, gastric bypass surgery and sleeve gastrectomy can induce malabsorption and may accentuate ID. The present review explores the burden and characteristics of ID and anemia in obese patients after bariatric surgery, accounting for gastric bypass technique (Roux-en-Y gastric bypass—RYGB) and sleeve gastrectomy (SG). After bariatric surgery, obese subjects’ iron status should be monitored, and they should be motivated to use adequate and recommended iron supplementation.
Bariatric surgery , Iron deficiency , Iron metabolism , Iron supplement , Obesity
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Council for Nutritional and Environmental Medicine, Toften 24, Mo i Rana, 8610, Norway
Department of Chemistry and Pharmacy, University of Sassari, Via Vienna 2, Sassari, 07100, Italy
Department of Neurology, Ophthalmology and Otolaryngology, Semey Medical University, Semey, 071400, Kazakhstan
CONEM Kazakhstan Environmental Health and Safety Research Group, Semey Medical University, Semey, 071400, Kazakhstan
Faculty of Medicine, Ovidius University of Constanta, Constanta, 900470, Romania
Research Department, Innlandet Hospital Trust, Brumunddal, 2380, Norway
Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, 37134, Italy
CONEM Scientific Secretary, Verona, 37134, Italy
Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), 31975/148, Karaj, Iran
Council for Nutritional and Environmental Medicine
Department of Chemistry and Pharmacy
Department of Neurology
CONEM Kazakhstan Environmental Health and Safety Research Group
Faculty of Medicine
Research Department
Department of Neurosciences
CONEM Scientific Secretary
Razi Vaccine and Serum Research Institute
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