ImpFact4.Herbal Substances with Antiviral Effects: Features and Prospects for the Treatment of Viral Diseases with Emphasis on Pro-Inflammatory Cytokines
Bjørklund G. Lysiuk R. Semenova Y. Lenchyk L. Dub N. Doşa M.D. Hangan T.
2024Bentham Science Publishers
Current Medicinal Chemistry
2024#31Issue 4393 - 409 pp.
Viral diseases have a significant impact on human health, and three novel coro-naviruses (CoV) have emerged during the 21st century. In this review, we have emphasized the potential of herbal substances with antiviral effects. Our investigation focused on the features and prospects of viral disease treatment, with a particular emphasis on proinflammatory cytokines. We conducted comprehensive searches of various databases, including Science Direct, CABI Direct, Web of Science, PubMed, and Scopus. Cytokine storm mechanisms play a crucial role in inducing a pro-inflammatory response by triggering the expression of cytokines and chemokines. This response leads to the recruitment of leukocytes and promotes antiviral effects, forming the first line of defense against viruses. Numerous studies have investigated the use of herbal medicine candidates as im-munomodulators or antivirals. However, cytokine-storm-targeted therapy is recommended for patients with acute respiratory distress syndrome caused by SARS-CoV to survive severe pulmonary failure. Our reviews have demonstrated that herbal formulations could serve as alternative medicines and significantly reduce complicated viral infections. Furthermore, they hold promising potential as specific antiviral agents in experimental animal models.
antivirals , COVID-19 , cytokines , herbal medicine , pro-inflammatory response , SARS-CoV-2
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Department of Research, Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway
Department of Pharmacognosy and Botany, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
CONEM Ukraine Life Science Research Group, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
School of Medicine, Nazarbayev University, Astana, Kazakhstan
Department of Research, National University of Pharmacy, Kharkiv, Ukraine
CONEM Ukraine Pharmacognosy and Natural Product Chemistry Research Group, National University of Pharmacy, Kharkiv, Ukraine
Andrei Krupynskyi Lviv Medical Academy, Lviv, Ukraine
Faculty of Medicine, Ovidius University of Constanta, Constanta, Romania
Department of Research
Department of Pharmacognosy and Botany
CONEM Ukraine Life Science Research Group
School of Medicine
Department of Research
CONEM Ukraine Pharmacognosy and Natural Product Chemistry Research Group
Andrei Krupynskyi Lviv Medical Academy
Faculty of Medicine
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