Coenzyme Q10 for Enhancing Physical Activity and Extending the Human Life Cycle
Bjørklund G. Semenova Y. Gasmi A. Indika N.-L.R. Hrynovets I. Lysiuk R. Lenchyk L. Uryr T. Yeromina H. Peana M.
2024Bentham Science Publishers
Current Medicinal Chemistry
2024#31Issue 141804 - 1817 pp.
Background: Coenzyme Q (CoQ) is an enzyme family that plays a crucial role in maintaining the electron transport chain and antioxidant defense. CoQ10 is the most common form of CoQ in humans. A deficiency of CoQ10 occurs naturally with aging and may contribute to the development or progression of many diseases. Besides, cer-tain drugs, in particular, statins and bisphosphonates, interfere with the enzymes responsi-ble for CoQ10 biosynthesis and, thus, lead to CoQ10 deficiency. Objectives: This article aims to evaluate the cumulative studies and insights on the topic of CoQ10 functions in human health, focusing on a potential role in maintaining physical activity and extending the life cycle. Results: Although supplementation with CoQ10 offers many benefits to patients with cardiovascular disease, it appears to add little value to patients suffering from statin-associat-ed muscular symptoms. This may be attributed to substantial heterogeneity in doses and treatment regimens used. Conclusion: Therefore, there is a need for further studies involving a greater number of patients to clarify the benefits of adjuvant therapy with CoQ10 in a range of health conditions and diseases.
aging , antioxidant , Coenzyme Q10 , physical activity , supplementation , ubiquinol , ubiquinone
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Council for Nutritional and Environmental Medicine (CONEM), Mo i Rana, Norway
Department of Surgery, Nazarbayev University School of Medicine, Astana, Kazakhstan
Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France
Department of Biochemistry, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka
Department of Drug Technology and Biopharmaceutics, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
CONEM Ukraine Life Science Research Group, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Department of Phar-macognosy and Botany, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine
Department of Pharmaceutical Technologies and Quality of Medicines, Institute for Advanced Training of Pharmacy Specialists, National University of Pharmacy, Kharkiv, Ukraine
CONEM Ukraine Pharmacognosy and Natural Product Chemistry Research Group, National University of Phar-macy, Kharkiv, Ukraine
Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, Sassari, 07100, Italy
Council for Nutritional and Environmental Medicine (CONEM)
Department of Surgery
Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée
Department of Biochemistry
Department of Drug Technology and Biopharmaceutics
CONEM Ukraine Life Science Research Group
Department of Phar-macognosy and Botany
Department of Pharmaceutical Technologies and Quality of Medicines
CONEM Ukraine Pharmacognosy and Natural Product Chemistry Research Group
Department of Chemical
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