Study of the Formation and Maintenance of Immunological Memory Cells in Response to Immunization for Myxomatosis and Viral Hemorrhagic Disease in Rabbits
Biyashev B. Zhanabayev S. Valdovska A.
15 April 2024Unique Scientific Publishers
International Journal of Veterinary Science
2024#13Issue 3334 - 340 pp.
The study focused on immunological responses to vaccines in laboratory rabbits. It aimed to explore the development and longevity of immunological memory. Two vaccine types, live attenuated and inactivated, were compared, specifically for myxomatosis and viral hemorrhagic disease in rabbits. Following vaccination, animals exhibited a significantly higher antibody titer against inactivated viral hemorrhagic disease compared to live attenuated myxomatosis. The bodys primary response to viral pathogens involved an increase in segmented neutrophils, indicating cellular activation. Starting from days 7-14, serum antibody levels increased, peaking within the first month post-vaccination and declining within 9-12 months, dependent on the pathogen source. The rate of antibody increase was influenced by booster dose timing, with shorter intervals resulting in higher intensity antibody production. Overall, this research informs vaccination strategies and immunological memory.
Antibody , Antibody titer , Antigen , Associated vaccine , Myxomatosis , Rabbit viral hemorrhagic disease
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Department of Microbiology, Virology and Immunology, Kazakh National Agrarian Research University, Almaty, Kazakhstan
Faculty of Veterinary Medicine, Latvia University of Life Sciences and Technologies, Jelgava, Latvia
Department of Microbiology
Faculty of Veterinary Medicine
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