Predictive Value of Basal Serum Progesterone for Successful IVF in Endometriosis Patients: The Need for a Personalized Approach
Bila J. Dotlic J. Radjenovic S.S. Vidakovic S. Tulic L. Micic J. Stojnic J. Babovic I. Dmitrovic A. Chiantera V. Laganà A.S. Terzic M.
October 2022MDPI
Journal of Personalized Medicine
2022#12Issue 10
The data regarding the role of progesterone (P4) in reproductive events of endometriosis patients are limited. This prospective study aimed to examine the predictive value of basal P4 serum levels for successful in vitro fertilization (IVF) in patients with primary infertility and endometriosis. The study included 73 patients divided according to endometriosis treatment (surgery vs. control—no treatment). The general data, basal hormonal status, and pregnancy rates were determined for every patient. Clinical pregnancy was achieved in 40.3% of patients, and more often in patients treated for endometriosis before IVF. The regression analysis showed that higher basal P4 serum levels were associated with achieving pregnancy through IVF. When regression was adjusted for the patient and IVF characteristics, higher basal P4 serum levels were associated with pregnancy achievement in both groups of women, along with the basal serum levels of FSH, LH, and AMH; EFI score; and stimulation protocol. The ROC analysis showed that the basal P4 serum level for successful IVF should be ≥0.7ng/mL. The basal P4 serum level cut-off for IVF success in endometriosis patients was determined for the first time. Constructed models for IVF success prediction emphasize the importance of determining the basal P4 serum levels for the personalized treatment of endometriosis-related infertility.
endometriosis , in vitro fertilization , personalized approach , progesterone , surgery
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Clinic of Obstetrics and Gynecology, University Clinical Centre of Serbia, Dr Koste Todorovica 26, Belgrade, 11000, Serbia
Faculty of Medicine, University of Belgrade, Dr Subotica Starijeg 8, Belgrade, 11000, Serbia
Unit of Gynecologic Oncology, ARNAS “Civico-Di Cristina-Benfratelli”, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, 90127, Italy
Department of Medicine, School of Medicine, Nazarbayev University, Zhanybek-Kerey Khans Street, 5/1, Nur-Sultan, 010000, Kazakhstan
Clinical Academic Department of Women’s Health, National Research Center for Maternal and Child Health, Corporate Fund “University Medical Center”, Turan Ave. 32, Nur-Sultan, 010000, Kazakhstan
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, 300 Halket Street, Pittsburgh, 15213, PA, United States
Clinic of Obstetrics and Gynecology
Faculty of Medicine
Unit of Gynecologic Oncology
Department of Medicine
Clinical Academic Department of Women’s Health
Department of Obstetrics
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