Accumulation and neuroprotective effects of lithium on hepatocellular carcinoma mice model
Bgatova N. Obanina N. Taskaeva I. Makarova V. Rakhmetova A. Shatskaya S. Khotskin N. Zavjalov E.
5 January 2024Elsevier B.V.
Behavioural Brain Research
2024#456
Aim: The peripheral tumor growth is accompanied by the accumulation of inflammatory mediators in the blood that can negatively influence blood-brain barrier function and neuronal structure and develop the cancer-associated depression. The aim of the study was to evaluate the neurobiological effects of lithium on hepatocellular carcinoma mice model. Methods: In this study we analyzed the locomotor activity of lithium-treated tumor-bearing mice using the Phenomaster instrument. Inductively coupled plasma mass-spectral analysis was used to determine lithium levels in blood, brain, liver, kidneys, tumors and muscle tissues. The prefrontal cortex neurons ultrastructure was assessed by transmission electron microscopy. Expression of BDNF, GRP78, EEA1, LAMP1, and LC3 beta in neurons was determined by immunohistochemical analysis. Results: A decrease in locomotor activity was found in animals with tumors. At the same time, the low expression levels of the neurotrophic factor BDNF and early endosomal marker EEA1 were revealed, as well as the decreased amount of synaptic vesicles and synapses was shown. Signs of endoplasmic reticulum stress and autophagy development in neurons of animals with tumors were noted. Lithium carbonate administration had a corrective effect on animals behavior and the prefrontal cortex neurons structure. Conclusions: In summary, lithium can restore the neuronal homeostasis in tumor-bearing mice.
Autophagy , Endoplasmic reticulum stress , Lithium , Prefrontal cortex neurons , Tumor , Ultrastructure
Text of the article Перейти на текст статьи
Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation
Toraigyrov University, Pavlodar, Kazakhstan
Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russian Federation
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russian Federation
Research Institute of Clinical and Experimental Lymphology – Branch of the Institute of Cytology and Genetics
Toraigyrov University
Institute of Solid State Chemistry and Mechanochemistry
Institute of Cytology and Genetics
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026