Attenuation processes in positive social emotion upregulation: Disentangling functional role of ventrolateral prefrontal cortex
Bezmaternykh D.D. Melnikov M.Y. Petrovskiy E.D. Mazhirina K.G. Savelov A.A. Shtark M.B. Vuilleumier P. Koush Y.
21 February 2025Elsevier Inc.
iScience
2025#28Issue 2
Positive emotions determine individual well-being and sustainable social relationships. Here, we examined the neural processes mediating upregulation of positive social emotions using functional magnetic resonance imaging in healthy female volunteers. We identified brain regions engaged in upregulation of positive social emotions and applied a parametric empirical Bayes approach to isolate modulated network connectivity patterns and assess how these effects relate to individual measures of social perception. Our findings indicate that upregulation of positive social emotions shapes the functional interplay between affective valuation and cognitive control functions. We revealed a selective increase of bilateral posterior ventrolateral prefrontal cortex (vlPFC) activity and attenuation of activity in right anterior vlPFC under control influences from more superior prefrontal regions. We also found that individual perception of sociality modulates connectivity between affective and social networks. This study expands our understanding of neural circuits required to balance positive emotions in social situations and their rehabilitative potential.
Behavioral neuroscience , Neuroscience
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Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russian Federation
Department of Biophysics, Biomedicine, and Neuroscience, Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan
International Tomography Center SB RAS, Novosibirsk, Russian Federation
Department of Neuroscience, Medical School, University of Geneva, Geneva, Switzerland
Swiss Center of Affective Sciences, University of Geneva, Campus Biotech, Geneva, Switzerland
Vladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Technology, Moscow, Russian Federation
Department of Biomedical Engineering, Yale University, New Haven, CT, United States
Institute of Molecular Biology and Biophysics
Department of Biophysics
International Tomography Center SB RAS
Department of Neuroscience
Swiss Center of Affective Sciences
Vladimir Zelman Center for Neurobiology and Brain Rehabilitation
Department of Biomedical Engineering
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