Novel ultra-stretchable and self-healing crosslinked poly (ethylene oxide)-cationic guar gum hydrogel

Bernal-Chávez S.A. Alcalá-Alcalá S. Almarhoon Z.M. Turgumbayeva A. Gürer E.S. De Los Dolores Campos-Echeverria M. Cortés H. Romero-Montero A. Del Prado-Audelo M.L. Sharifi-Rad J. Leyva-Gómez G.
December 2023 BioMed Central Ltd

Journal of Biological Engineering
2023 #17 Issue 1

Hydrogels are three-dimensional structures with specific features that render them useful for biomedical applications, such as tissue engineering scaffolds, drug delivery systems, and wound dressings. In recent years, there has been a significant increase in the search for improved mechanical properties of hydrogels derived from natural products to extend their applications in various fields, and there are different methods to obtain strengthened hydrogels. Cationic guar gum has physicochemical properties that allow it to interact with other polymers and generate hydrogels. This study aimed to develop an ultra-stretchable and self-healing hydrogel, evaluating the influence of adding PolyOX [poly(ethylene oxide)] on the mechanical properties and the interaction with cationic guar gum for potential tissue engineering applications. We found that variations in PolyOX concentrations and pH changes influenced the mechanical properties of cationic guar gum hydrogels. After optimization experiments, we obtained a novel hydrogel, which was semi-crystalline, highly stretchable, and with an extensibility area of approximately 400 cm², representing a 33-fold increase compared to the hydrogel before being extended. Moreover, the hydrogel presented a recovery of 96.8% after the self-healing process and a viscosity of 153,347 ± 4,662 cP. Therefore, this novel hydrogel exhibited optimal mechanical and chemical properties and could be suitable for a broad range of applications in different fields, such as tissue engineering, drug delivery, or food storage.

Cationic guar gum , Hydrogel , Poly(ethylene oxide) , Soft tissues , Tissue engineering , Wounds

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Departamento de Ciencias Químico-Biológicas, Universidad de Las Américas Puebla, Ex-Hda. de Sta. Catarina Mártir, Cholula, Puebla, 72820, Mexico
Laboratorio de Tecnología Farmacéutica, Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Morelos, Cuernavaca, Mexico
Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia
Higher School of Medicine, Al-Farabi Kazakh National University, Almaty, Kazakhstan
School of Pharmacy, JSC “S.D. Asfendiyarov Kazakh National Medical University”, Almaty, Kazakhstan
Department of Pharmacognosy, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Turkey
Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Ciudad de Mexico, 04510, Mexico
Laboratorio de Medicina Genómica, Departamento de Genómica, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Ciudad de México, 14389, Mexico
Tecnologico de Monterrey, Campus Ciudad de México, Ciudad de Mexico, 14380, Mexico
Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador

Departamento de Ciencias Químico-Biológicas
Laboratorio de Tecnología Farmacéutica
Department of Chemistry
Higher School of Medicine
School of Pharmacy
Department of Pharmacognosy
Departamento de Farmacia
Laboratorio de Medicina Genómica
Tecnologico de Monterrey
Facultad de Medicina

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