Overview of the Biological Activity of Anthraquinons and Flavanoids of the Plant Rumex Species
Berillo D. Kozhahmetova M. Lebedeva L.
February-2 2022MDPI
Molecules
2022#27Issue 4
Rumex confertus belongs to the genus Rumex and is classified as an invasive parasitic plant in agriculture. Despite other Rumex species being widely used in herbal medicine due to their antimicrobial, antioxidant, antitumor, and anti-inflammatory effects, there are almost no information about the potential of Rumex confertus for the treatment of various diseases. In this review we analyzed scientific articles revealing properties of Rumex plant’s substances against cancer, diabetes, pathogenic bacterial invasions, viruses, inflammation, and oxidative stress for the past 20 years. Compounds dominating in each composition of solvents for extraction were discussed, and common thin layer chromatography(TLC) and high performance liquid chromatography(HPLC) methods for efficient separation of the plant’s extract are included. Physico-chemical properties such as solubility, hydrophobicity (Log P), pKa of flavonoids, anthraquinones, and other derivatives are very important for modeling of pharmacokinetic and pharmacodynamics. An overview of clinical studies for abounded selected substances of Rumex species is presented.
Anthraquinone derivatives , Emodin , Epigallocatechin , Epigallocatechin gallate , Flavonoids , Herbal medicine , Rumex confertus
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Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany School of Pharmacy, Asfendiyarov Kazakh National Medical University, Almaty, 050040, Kazakhstan
Department of Biotechnology, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department of Molecular Biology and Genetics, Al-Farabi Kazakh National University, Almaty, 050040, Kazakhstan
Department of Pharmaceutical and Toxicological Chemistry
Department of Biotechnology
Department of Molecular Biology and Genetics
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