Polymorphism of the NIPAL1 Gene rs135173498 as a Marker of Embryonic Lethality in Auliekol Cattle
Belaya A.V. Klimanova E.A. Norkina V.M. Beishova I.S.
January 2025Pleiades Publishing
Russian Journal of Genetics
2025#61Issue 156 - 62 pp.
Abstract—It was found that, in Auliekol cattle, SNP G/A rs135173498 associated with live weight at birth (p‑value = 2.71E-06) is characterized by the absence of live-born calves homozygous for the rare genotype with a significant sample size of 497 animals. At the same time, calves with a heterozygous genotype were not characterized by a decrease in live weight at birth relative to the values of this indicator for the sample as a whole. The article analyzes possible mechanisms for the development of the phenotypic effect of SNP rs135173498 of the NIPAL1 gene as a factor of embryonic lethality in Auliekol cattle, and, presumably, in the Kazakh Whiteheaded, Aberdeen Angus, and Charolais breeds.
3-untranslated regions , cattle , embryonic lethality , genetic marker , genome-wide association study , GWAS , QTL , rs135173498/NIPAL1
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Maksim Tank Belarusian State Pedagogical University, Minsk, 220030, Belarus
Novosibirsk State Agrarian University, Novosibirsk, 630039, Russian Federation
Zhangir Khan West Kazakhstan Agrarian Technical University, Uralsk, 09000, Kazakhstan
Maksim Tank Belarusian State Pedagogical University
Novosibirsk State Agrarian University
Zhangir Khan West Kazakhstan Agrarian Technical University
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