Combined Use of Inhaled and Intravenous Colistin in a Patient with Acute Lymphoblastic Leukemia Complicated by Multi-Organ Failure and Sepsis: A Case Report
Bekniyazova A. Maidan A. Mishutin I. Bakhytzhan S. Yessenbayeva G.
2025National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2025#22Issue 393 - 97 pp.
Sepsis and subsequent organ dysfunction are significant complications in patients with acute lymphoblastic leukemia. This case report details the successful use of combined inhaled and intravenous colistin in a 22-year-old male with high-risk acute lymphoblastic leukemia who developed tumor lysis syndrome, febrile neutropenia, respiratory failure, sepsis, septic shock, capillary leak, and prolonged mechanical ventilation requiring tracheostomy. Colistin inhalation, administered via a vibrating mesh nebulizer, was well-tolerated and led to clinical improvement. This report contributes to the growing evidence supporting the adjunctive use of inhaled colistin in multidrug-resistant infections, particularly in immunocompromised patients.
case report , colistin , leukemia , multidrug-resistant , multiple organ failure , sepsis
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Department of Anesthesiology and Intensive Care, Astana Medical University, Astana, Kazakhstan
JSC Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Oncohematology Intensive Care Unit, National Research Oncology Centre, Astana, Kazakhstan
Department of Anesthesiology, Intensive care and Hyperbaric oxygenation, Municipal Hospital №1, Astana, Kazakhstan
Department of Anesthesiology and Intensive Care
JSC Asfendiyarov Kazakh National Medical University
Oncohematology Intensive Care Unit
Department of Anesthesiology
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