Cardiac Autonomic Neuropathy Is Not Associated with Apolipoprotein E Gene Isoforms in the Kazakh Population: A Case–Control Study
Bekenova N. Aitkaliyev A. Vochshenkova T. Kassiyeva B. Benberin V.
September 2024Multidisciplinary Digital Publishing Institute (MDPI)
Diagnostics
2024#14Issue 17
The absence of an early diagnosis of cardiac autonomic neuropathy might increase the risk of the disease, progressing to an irreversible stage. Therefore, this study aims to investigate the APOE gene isoforms in patients with cardiac autonomic neuropathy to identify early markers for predicting this disease in the Kazakh population. A total of 147 patients with cardiac neuropathy and 153 controls were examined in this case–control study. Patients were genotyped for two polymorphisms of the APOE gene using real-time PCR. Statistical calculations were performed using binary logistic regression. As a result of our study, we found that there was no statistically significant difference in the frequency of any APOE gene isoforms (APOE (ε2/ε2), APOE (ε2/ε3), APOE (ε2/ε4), APOE (ε3/ε3), or APOE (ε4/ε4)) between the patient group and the control group (p = 0.69, p = 0.64, p = 0.19, p = 0.22, p = 0.97, respectively). Thus, cardiac autonomic neuropathy is not associated with APOE gene isoforms in the Kazakh population.
APOE gene , cardiac autonomic neuropathy , Kazakh population , ε4 isoform
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Department of Science, Medical Centre Hospital of President’s Affairs Administration of the Republic of Kazakhstan, Astana, 010000, Kazakhstan
Institute of Innovative and Preventive Medicine, Astana, 010000, Kazakhstan
Department of Science
Institute of Innovative and Preventive Medicine
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