The Prevalence of Different Genotypic Forms of Familial Hypercholesterolemia in Relation to Race and Ethnicity
Bekbossynova M.S. Ivanova-Razumova T.V. Kali A.S. Sailybayeva A.I. Khamitov S.R. Oralbekova Z.O.
2024National Scientific Medical Center
Journal of Clinical Medicine of Kazakhstan
2024#21Issue 438 - 45 pp.
In the present study, a systematic literature review was conducted to evaluate the epidemiology of Familial hypercholesterolemia genetic variants according to different ethnic and racial background. Familial hypercholesterolemia (FH) is an inherited disease characterized by severe dyslipidemia and as a result high cardiovascular risk. Lipid profile of this patients distinguishes with increased cholesterol and low-density lipoprotein (LDL) blood levels. Databases PubMed, Web of Science, and Elsevier were searched and only peer-reviewed articles with a large number of contributors and sufficient prevalence and ethnicity data were included. Diagnosis of FH was based on genetic testing or clinical criteria. The results of the study indicate inadequate and untimely diagnosis of FH, resulting in inadequate treatment. To date, only 9% of countries have statistical data on the FH prevalence among their citizens. In order to develop effective prevention strategies for cardiovascular diseases associated with FH, further research is needed to obtain accurate epidemiological data, including the race and ethnicity of patients. This will allow to optimize strategies for reducing the social-economic burden of preventable cardiovascular disease associated with FH.
cardiovascular disease , Familial hypercholesterolemia , genes , low-density lipoprotein
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“University Medical Center” Corporate Fund, National Cardiac Surgery Center, Astana, Kazakhstan
“University Medical Center” Corporate Fund
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