Improvements in Cardiopulmonary Exercise Test Results in Atrial Fibrillation Patients After Radiofrequency Ablation in Kazakhstan
Beisenbayeva A. Bekbossynova M. Bakytzhanuly A. Aleushinova U. Bekmetova F. Chinybayeva A. Abdrakhmanov A. Beyembetova A.
November 2024Multidisciplinary Digital Publishing Institute (MDPI)
Diagnostics
2024#14Issue 21
This prospective study evaluates the impact of radiofrequency ablation (RFA) on cardiorespiratory indicators in patients with long-standing persistent atrial fibrillation admitted to the Heart Center UMC between January 2022 and April 2024 in Astana, Kazakhstan. The study aims to assess the functional cardiac benefits of RFA. Out of 717 registered atrial fibrillation patients, 104 were examined before and 3 months after ablation, focusing on cardiorespiratory parameters. A before-and-after analysis using linear mixed models was applied to evaluate changes in cardiorespiratory parameters post-RFA. Significant improvements were noted across various measures. VO2 max increased from 11.5 ± 4.4 mL/kg/min to 18.0 ± 4.5 mL/kg/min (p < 0.001). Oxygen uptake improved from 7.2 ± 2.6 mL/beat to 11.0 ± 3.4 mL/beat (p < 0.001). The 6-min walking test distance rose from 306 ± 82 m to 400 ± 48 m (p < 0.001). METs increased from 4.4 ± 1.6 to 8.0 ± 1.3 (p < 0.001). Heart rate at peak exercise decreased from 175.5 ± 18.6 to 147.2 ± 12.3 beats per minute (p < 0.001). NT-proBNP levels decreased from 1357 ± 1182 to 415 ± 339 pg/mL (p < 0.001). Patients with persistent atrial fibrillation undergoing RFA showed functional improvements in CPET indicators such as VO2 max, METs, O2 pulse, heart rate, and the 6-min walking test. Improvements were also seen in Nt-proBNP analysis. These results emphasize the need for longitudinal follow-up to optimize outcomes and minimize medical risks.
6-min walking test , arrythmia , atrial fibrillation , cardiorespiratory exercise testing , CPET , heart failure , METs , Nt-proBNP , radiofrequency ablation , VO2 max
Text of the article Перейти на текст статьи
Corporate Fund ”University Medical Center”, Heart Center, Astana, 010000, Kazakhstan
Department of Cardiology, Non-Profit Joint Stock Company “Medical University Astana”, Astana, 010000, Kazakhstan
Republican Specialized Scientific Practical-Medical Center of Cardiology, Astana, 010000, Kazakhstan
Department of Medicine, School of Medicine, Nazarbayev University, Astana, 010000, Kazakhstan
Corporate Fund ”University Medical Center”
Department of Cardiology
Republican Specialized Scientific Practical-Medical Center of Cardiology
Department of Medicine
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026