Synergistic Effects of Hydrogel Nanoparticles and Docetaxel for Prostate Cancer: A Review
Bazilbayev S. Jaafar Abdulsahib A.M. Hanoon H.N. Hulail H.M. Abid F.M. Shirshab S. Gati M.A. Abass R.A.R. Umid M. Furkatjon A. Khudaybergan K. Inomjon M. Boymatova Z.
April 2025University of Kashan
Journal of Nanostructures
2025#15Issue 2762 - 770 pp.
Prostate cancer remains one of the most prevalent malignancies affecting men worldwide, necessitating continuous advancements in therapeutic strategies to improve clinical outcomes. Docetaxel, a microtubule-stabilizing chemotherapeutic agent, has demonstrated significant efficacy in managing metastatic castration-resistant prostate cancer. However, its clinical utility is frequently compromised by dose-dependent toxicity, suboptimal bioavailability, and the emergence of drug resistance. Nanotechnology-based drug delivery systems have gained attention for their ability to enhance therapeutic precision, improve drug solubility, and reduce systemic side effects. Hydrogel nanoparticles offer a promising platform for encapsulating docetaxel, providing controlled and sustained drug release, improved tumor selectivity, and enhanced intracellular drug accumulation. This review examines the synergistic potential of hydrogel nanoparticles and docetaxel in prostate cancer therapy, highlighting mechanistic insights into improved drug delivery efficiency, apoptotic induction, and resistance mitigation. By integrating hydrogel nanoparticle-based formulations, the therapeutic index of docetaxel can be optimized, contributing to more effective and personalized prostate cancer treatment approaches.
Cancer , Docetaxel , Drug delivery , Hydrogel , Nanoparticles , Prostate
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Department of Biochemistry, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Pharmacology, College of Pharmacy, University of Al-Ameed, Iraq
Department of Pharmacy, Al-Turath University, Iraq
Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq
Al-Hadi University College, Baghdad, Iraq
Warka University College, Iraq
College of Health and Medical Technologies, National University of Science and Technology, Dhi Qar, Iraq
Mazaya University College, Iraq
Bukhara State Medical Institute named after Abu Ali Ibn Sina, Bukhara, Uzbekistan
Department of Pedagogy and Psychology, Kokand University, Fergana, Uzbekistan
Urgench State University, Khorezm, Urganch, Uzbekistan
Mamun University, Uzbekistan
Department of Social and Economic Sciences, Kokand University, Andijan Branch, Andijan, Uzbekistan
Department of Biochemistry
Department of Pharmacology
Department of Pharmacy
Department of Medical Laboratories Technology
Al-Hadi University College
Warka University College
College of Health and Medical Technologies
Mazaya University College
Bukhara State Medical Institute named after Abu Ali Ibn Sina
Department of Pedagogy and Psychology
Urgench State University
Mamun University
Department of Social and Economic Sciences
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