Investigation of the sensitivity of human A549 cells to paclitaxel and sesquiterpene lactone alantolactone via apoptosis induction
Bayar I. Erzurumlu Y. Akkoc S. Bulut Z. Nizamlioglu M.
August 2025Springer Science and Business Media Deutschland GmbH
Naunyn-Schmiedebergs Archives of Pharmacology
2025#398Issue 810625 - 10633 pp.
Alantolactone (ALA), a sesquiterpene lactone compound obtained from Inula helenium root, is known to have anticancer activity in many types of cancer. Paclitaxel (PAX) is an effective first-line chemotherapeutic drug and is widely used in the treatment of lung cancer. The in vitro anticancer efficacy of combined treatment of ALA with PAX was investigated in the A549 human lung cancer cell line. The results show that ALA potentiated the effect of PAX-induced growth restriction and apoptosis in A549 cells. The combined administration more effectively decreased the Bcl-2 expression and increased Bax gene expression in cells compared to ALA or PAX alone. Also, co-treatment of ALA and PAX caused apoptotic nuclear formations. Additionally, coadministration increased the caspase-3 and caspase-9 levels more than PAX or ALA alone. The increase in NF-κB gene expression levels suggests that an NF-κB-independent apoptotic trigger mechanism operates in cells. Together, the present in vitro findings suggest that ALA may contribute as a potential therapeutic strategy in the treatment of lung cancer.
A549 , Alantolactone , Apoptosis , Lung cancer , Paclitaxel
Text of the article Перейти на текст статьи
Department of Biochemistry, Faculty of Veterinary Medicine, Selcuk University, Konya, Turkey
Department of Pharmaceutical Research and Development, Institute of Health Sciences, Suleyman Demirel University, Isparta, Turkey
Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, Suleyman Demirel University, Isparta, Kazakhstan
Faculty of Engineering and Natural Sciences, Bahcesehir University, Istanbul, Turkey
Department of Biochemistry, Faculty of Veterinary Medicine, Dokuz Eylul University, Izmir, Turkey
Department of Biochemistry
Department of Pharmaceutical Research and Development
Department of Basic Pharmaceutical Sciences
Faculty of Engineering and Natural Sciences
Department of Biochemistry
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026