Chromium as a Risk Factor for Breast Cancer: A Meta-Analysis
Batyrova G. Kononets V. Amanzholkyzy A. Tlegenova Z. Umarova G.
1 December 2022NLM (Medline)
Asian Pacific journal of cancer prevention : APJCP
2022#23Issue 123993 - 4003 pp.
BACKGROUND: Chromium (Cr) is a transition metal, natural element. Chromium is the 21st most abundant element in Earths crust. Cr is found in soil, rocks and living organisms. It may have various oxidation states, from -2 to +6, but most of these states are too unstable to exist in any significant quantities. The purpose of this review and meta-analysis is to critically assess the scientific evidence on the carcinogenic effects of chromium (Cr) and to determine whether there is currently sufficient evidence to suggest that that there is a link between chromium levels in hair and blood serum and breast cancer in women. MATERIAL AND METHODS: Research on the relationship between heavy metal chromium and the risk of developing breast cancer has been searched in PubMed, EMBASE, Web of Science, Scopus among papers published between January 2000 and September 2020. The search used the following terms (MeSH): breast cancer, women, trace elements, metals, chromium, chemically-induced, hair, serum using additional terms. RESULTS: In the second group of comparisons of women from ecologically clean districts of Aktobe Region, there were significantly lower indicators of the microelements in tumor tissue. The amount of Fe ranges from 38.46 to 65.39 ug/g (average 49.56±5.81 ug/g), Cu from 2.8 to 6.69 ug/g (average 5.06±1.01 ug/g), Zn from 1.89 to 5.38 ug/g (average 3.88±0.89 ug/g), Cr from zero to 6,1 ug/g (average 2.13±1.29 ug/g), Ni from 0.11 to 0.42 ug/g (average 0.28±0.067 ug/g) и Pb from zero to 0.19 ug/g (average 0.098±0.06 ug/g). CONCLUSION: The article established that women who live or work in ecologically polluted areas or have problems with micronutrient exchange need in-depth screening and more frequent screening for early detection of pre- and breast cancer.
Biomarker , Breast , chromium , dependencies , elements
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Department of Clinical Laboratory and Visual Diagnostics, West Kazakhstan Marat Ospanov Medical University, Republic of Kazakhstan, Aktobe, Kazakhstan
Department of Molecular Biology and Medical Genetics, West Kazakhstan Marat Ospanov Medical University, Republic of Kazakhstan, Aktobe, Kazakhstan
Department of Normal Phiziology, West Kazakhstan Marat Ospanov Medical University, Republic of Kazakhstan, Aktobe, Kazakhstan
Department of Internal Diseases No. 2, West Kazakhstan Marat Ospanov Medical University, Republic of Kazakhstan, Aktobe, Kazakhstan
Department of Evidence-Based Medicine and Scientific Management, West Kazakhstan Marat Ospanov Medical University, Republic of Kazakhstan, Aktobe, Kazakhstan
Department of Clinical Laboratory and Visual Diagnostics
Department of Molecular Biology and Medical Genetics
Department of Normal Phiziology
Department of Internal Diseases No. 2
Department of Evidence-Based Medicine and Scientific Management
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