Individualized parameters for mechanical ventilation during thoracic operations: Optimizing respiratory support

Batyrkhanov M. Mukhtarkhanova D.
2025 Canadian Society of Respiratory Therapists

Canadian Journal of Respiratory Therapy
2025 #61 Issue 1 117 - 127 pp.

Introduction Adequate respiratory support with mechanical lung ventilation (MLV) is crucial for maintaining gas exchange and pulmonary circulation hemodynamics in patients with severe lung diseases in the perioperative period. However, the selection of optimal parameters for ventilation is often a serious problem, which can lead to the development of complications and worsening of treatment outcomes. Purpose This study aimed to evaluate the effectiveness of the developed method of individual calculation of ventilator parameters to optimize respiratory support in patients with various lung diseases undergoing surgical intervention. Methods This study used a prospective clinical approach to optimize mechanical lung ventilation by calculating individualized ventilatory parameters based on each patient’s lung function during surgery. Results The results showed that in patients with unilateral lesions, the application of the developed method achieved PaO2 94.1±6.7 mmHg and PaCO2 36.2±4.5 mmHg, mean pulmonary artery pressure 25.8±3.6 mmHg, as well as cardiac output 4.8±0.8 l/min and oxygen transport 489±77 ml/min at the final post-operative stage. Even in bilateral diffuse lesions, individualized ventilatory parameters provided PaO2 79.6±11.3 mmHg and reduced bronchial resistance to 11.4±3.6 cmH2O/l/sec after surgery. Despite gross respiratory dysfunction, the personalized approach maintained PaO2 79.2±9.7 mmHg and PaCO2 46.1±6.3 mmHg postoperatively in patients with congenital pulmonary malformations such as cystic hypoplasia. Conclusion This study demonstrates the high efficacy of personalized approaches to respiratory support management to improve patient outcomes and reduce the risk of complications in patients with lung disease in the perioperative period.

bronchiectasis , COPD , cystic hypoplasia , haemodynamics , hemodynamics , lung cancer , pulmonary insufficiency , pulmonology

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Department of Surgery with Courses In Reanimatology and Anesthesiology, Kazakh-Russian Medical University, Kazakhstan
Department of Cardiology, Asfendiyarov Kazakh National Medical University, Kazakhstan

Department of Surgery with Courses In Reanimatology and Anesthesiology
Department of Cardiology

10 лет помогаем публиковать статьи Международный издатель

Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026