An updated systematic review about various effects of microplastics on cancer: A pharmacological and in-silico based analysis
Baspakova A. Zare A. Suleimenova R. Berdygaliev A.B. Karimsakova B. Tussupkaliyeva K. Mussin N.M. Zhilisbayeva K.R. Tanideh N. Tamadon A.
February 2025Elsevier Ltd
Molecular Aspects of Medicine
2025#101
Microplastics (MPs) are known as substantial environmental and health threats because of their pervasive existence and potential function in human diseases. This study is the first research in which a comprehensive analysis of various impacts of MPs on cancer cells is performed through pharmacological and in silico approaches. Moreover, our results demonstrate that MPs have both promotive and suppressive impacts on cancer cells, changing some of the important features of these kinds of cells including cellular viability, migration, metastasis, and apoptosis. Furthermore, the present study displayed that AP-2 complex subunit mu-1 (AP2M1), Asialoglycoprotein receptor 2 (ASGR2), Bax inhibitor-1 (BI-1), and Ferritin Heavy Chain, and pivotal role in the progression of cancers mediated by MPs. Moreover, our in-silico analysis identified Goserelin, Paclitaxel, Raloxifene, Exemestane, Epirubicin, Trametinib, Vemurafenib, Pactitaxel, and Sorafenib as potential anticancer agents for curing MPS-based cancer. Besides, our results demonstrated that MPs can exacerbate the development of tumor cells by affecting some important mechanisms including oxidative stress, immune suppression, and adjusting of critical signaling pathways. Interestingly, some sorts of MPs also displayed suppressive effects on cancer cells in some particular contexts, highlighting their complicated biological roles in different biological interactions. Ultimately the present survey tries to demonstrate the crucial roles of MPs in cancer cells and the different mechanisms that occur in the mentioned cells in order to emphasize performing more studies about clarifying the roles of MPs in carcinogenesis.
Antitumor drug , Cancer , In silico Simulation , Microplastic , Pharmacology
Text of the article Перейти на текст статьи
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Epidemiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
R&D Department, PerciaVista Co., Shiraz, Iran
Department of Public Health and Hygiene, Astana Medical University, Astana, Kazakhstan
Department of Nutrition, Kazakh National Medical University named after S. D. Asfendiyarov, Almaty, Kazakhstan
Department of General Medical Practice №1, West Kazakhstan Marat Ospanov Medical University, Aktobe, 030012, Kazakhstan
Department of Surgery No. 2, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Languages, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Department of Pharmacology, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan
Stem Cells Technology Research Center
Department of Epidemiology
R&D Department
Department of Public Health and Hygiene
Department of Nutrition
Department of General Medical Practice №1
Department of Surgery No. 2
Department of Languages
Department of Pharmacology
Department of Natural Sciences
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026