COMPARATIVE ANALYSIS OF THE EFFECTIVENESS OF PROGRAMS AND PERINATAL OUTCOMES AFTER FROZEN-THAWED EMBRYO TRANSFER DEPENDING ON POST-TRANSFER SUPPORT MEDICATIONS

Bashmakova N.V. Lokshin V.N. Isenova S.S. Khramtsova A.Y. Dankova I.V. Ryabukhin I.V.
2023 Bionika Media Ltd.

Akusherstvo i Ginekologiya (Russian Federation)
2023 #2023 Issue 7 103 - 108 pp.

Choosing the optimal protocol for preparing the endometrium for frozen-thawed embryo transfer is the most important issue of personalized selection of therapy for improving the effectiveness of assisted reproductive technology (ART) programs. Objective: To evaluate the effectiveness of frozen-thawed embryo transfer programs and pregnancy outcomes depending on the type of progestogen used for secretory endometrial transformation and post-transfer support. Materials and methods: The study included 334 infertile women who had frozen-thawed own embryo transfer with hormone replacement therapy cycle in the Assisted Reproduction Department, Urals Scientific Research Institute for Maternal and Child Care. The first group consisted of 224 patients who took dydrogesterone (30 mg/ day orally) for full secretory transformation of the endometrium, the second group included 110 patients who were prescribed micronized vaginal progesterone (600 mg/day). Results: The clinical pregnancy rate in group 1 was 86/224 (38.39%), and it was 38/110 (34.54%) in group 2; however, there was no statistical difference depending on the type of progestogen which was used to support the luteal phase (p=0.468). The term delivery rate in the group of women taking dydrogesterone was 42/86 (48.83%), and it was 14/38 (36.84%) in the comparison group (p=0.216). There was a tendency to a decrease in the preterm birth rate in group 1, namely, 6/86 (6.97%), while it was 6/38 (15.79%) in group 2 (p=0.126). There was no statistically significant difference in the rate of termination of pregnancy before 22 weeks in both groups (p=0.743): the rate of miscarriage in group 1 was 38/86 (44.18%), and it was 18/38 (47.36%) in group 2. Conclusion: The data obtained in the study showed comparable effectiveness of progestogens in the clinical pregnancy rate and perinatal outcomes in the cycle of preparation for frozen-thawed embryo transfer. It is possible to use both micronized vaginal progesterone and dydrogesterone in cycles of hormone replacement therapy for preparing the endometrium for frozen-thawed embryo transfer.

assisted reproductive technologies , dydrogesterone , frozen-thawed embryo transfer , micronized progesterone , pregnancy after ART

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Urals Scientific Research Institute for Maternal and Child Care, Ministry of Health of Russia, Yekaterinburg, Russian Federation
PERSONA International Clinical Center for Reproductive Medicine, Almaty, Kazakhstan
Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan

Urals Scientific Research Institute for Maternal and Child Care
PERSONA International Clinical Center for Reproductive Medicine
Asfendiyarov Kazakh National Medical University

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