The mode of action of different organochlorine pesticides families in mammalians
Baratzhanova G. Fournier A. Delannoy M. Baubekova A. Altynova N. Djansugurova L. Cakir-Kiefer C.
September 2024Elsevier B.V.
Environmental Toxicology and Pharmacology
2024#110
Organochlorine pesticides (OCPs) show differences in their chemical structure, mechanism of toxicity, and target organisms. However, OCPs also have some common characteristics such as high persistence in the environment, bioaccumulation, and toxicity which lead to health issues. Nowadays, the toxicity of OCPs is well known, but we still do not know all the specific molecular mechanisms leading to their toxicity in mammalians. Therefore, this review aims to collect data about the mode of action of various classes of OCPs, highlighting their differences and common behavioural reactions in the human and animal body. To discuss the OCPs molecular pathways and fate in different systems of the body, three organochlorine insecticides were selected (Dichlorodiphenyltrichloroethane, Hexachlorocyclohexane and Chlordecone), regarding to their widespread use, with consequent effects on the ecosystem and human health. Their common biological responses at the molecular scale and their different interactions in human and animal bodies were highlighted and presented.
Chlordecone , DDT , HCH , mechanism , metabolism , Organochlorine pesticides
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Université de Lorraine, INRAE, L2A, Nancy, F-54000, France
Institute of Genetics and Physiology, Al-Farabi Avenue 93, Almaty, 050060, Kazakhstan
Al-Farabi Kazakh National University, Faculty of Biology and Biotechnology, Al-Farabi Avenue 71, Almaty, 050040, Kazakhstan
Université de Lorraine
Institute of Genetics and Physiology
Al-Farabi Kazakh National University
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026