The influence of advanced age and obesity on pregnancy course and outcome in patients with diabetes mellitus
Bapayeva G. Terzic S. Dotlic J. Togyzbayeva K. Bugibaeva U. Mustafinova M. Alisheva A. Karaman E. Terzic M. Laganà A.S.
2022Termedia Publishing House Ltd.
Przeglad Menopauzalny
2022#21Issue 3170 - 179 pp.
Introduction: Older women are at greater risk of suffering from a series of comorbidities such as obesity, diabetes, and hypertension that could negatively affect pregnancy course and outcomes. This study aims to investigate the impact of maternal age and pre-pregnancy body mass index (BMI) on pregnancy outcomes of women with diabetes mellitus (DM). Material and methods: The study included 323 diabetic pregnant women. All complications throughout pregnancy and the early neonatal period were noted. The women were divided into groups according to age decade and BMI. Results: 84.8% of women reported pregnancy complications, with a higher prevalence in obese women (p = 0.003). However, most children had a good outcome with few early neonatal complications (36.85%). Old and obese women with DM often showed complications, and their newborns had higher birth weight (p = 0.003) and more neonatal complications (p = 0.041). Maternal BMI (p = 0.016; OR = 1.064), but not age (p = 0.801), was found to be a significant predictor of pregnancy complications. Conclusions: Pregnant women with DM should be considered as high-risk patients. Advanced age and increased BMI prior to pregnancy are risk factors for pregnancy complications. Maternal obesity is the most important predictor of pregnancy complications in women with DM. Pregnancy outcome can be good for both mothers and children with a timely and adequate approach.
age , BMI , complications , diabetes mellitus , outcome , pregnancy
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Clinical Academic Department of Women’s Health, Corporate Fund “University Medical Centre”, Nur-Sultan, Kazakhstan
Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan, Kazakhstan
Clinic of Obstetrics and Gynaecology, Clinical Centre of Serbia, Belgrade, Serbia
School of Medicine, University of Belgrade, Belgrade, Serbia
Department of Obstetrics and Gynaecology, Faculty of Medicine, Van Yüzüncü Yıl University, Van, Turkey
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, School of Medicine, Pittsburgh, PA, United States
Unit of Gynecologic Oncology, ARNAS Civico – Di Cristina – Benfratelli, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy
Clinical Academic Department of Women’s Health
Department of Medicine
Clinic of Obstetrics and Gynaecology
School of Medicine
Department of Obstetrics and Gynaecology
Department of Obstetrics
Unit of Gynecologic Oncology
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