A randomized trial of the role of neutrophil mitochondrial dysfunction in the medical rehabilitation of patients receiving palliative chemotherapy for metastatic colorectal cancer

Baltabekov N.T. Panov S.A. Kashikova K.
May 2025 Edizioni Minerva Medica

Gazzetta Medica Italiana Archivio per le Scienze Mediche
2025 #184 Issue 5 443 - 451 pp.

BACKGROUND: Of the 7.3 billion people inhabiting our planet, there are nearly 20 million new cases of cancer and 9.7 million cancer deaths worldwide each year. World Health Organization (WHO) expects cancer incidence to increase by 77% by 2050, with more than 75% of cancer-related deaths occurring in low-and middle-income countries over the next decade. Therefore, one of the current prospectus challenges is to address the problem of finding a cheap and affordable way to restore health in humans during and after cancer treatment. METHODS: The study was planned to include 200 patients with colorectal cancer (CRC) from 19 regions of Kazakhstan. The efficacy of palliative therapy during four courses of folinic acid, 5-fluorouracil, and oxaliplatin (FOLFOX) chemotherapy in combination with sodium nucleinate in patients with metastatic CRC was evaluated in the main group. The efficacy of four courses of standard FOLFOX chemotherapy was evaluated in the control group. The results were evaluated with comparison of quality of life, dynamics of laboratory tests and overall survival in the main and control groups. potential correlations between the dynamics of mitochondrial dysfunction, patients’ quality of life. RESULTS: We confirmed the assumption that the use of sodium nucleonate increased the patient’s adaptation and probably improved the tumor microenvironment, which led to an improvement in the quality of life and will reduce the incidence of adverse effects. We also proposed a model of dynamic monitoring of the patient’s well-being, which consists of measuring the level of immunity, the proportion of cells with active mitochondria and the QLQ-CR29 questionnaire. CONCLUSIONS: Monitoring mitochondrial dysfunction during palliative therapy for CRC is a promising direction for improving quality of life and reducing 1-year mortality.

Colorectal neoplasms , Drug therapy , Mitochondria , Rehabilitation , Sodium nucleinate

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International Research Institute of Postgraduate Education, Almaty, Kazakhstan
Department of Intensive Care, Clinical Hospital of the Ministry of Defense of the Republic of Kazakhstan, Almaty, Kazakhstan
Caspian International School of Medicine, Almaty, Kazakhstan

International Research Institute of Postgraduate Education
Department of Intensive Care
Caspian International School of Medicine

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