Preparation of a Supramolecular Assembly of Vitamin D in a β-Cyclodextrin Shell with Silver Nanoparticles
Bakirova R.Y. Fazylov S.D. Iskineyeva A.S. Sarsenbekova A.Z. Sviderskiy A.K. Seilkhanov O.T. Mustafayeva A.K. Mendibayeva A.Z. Ashirbekova B.D. Agedilova M.T. Khabdolda G.
December 2025Multidisciplinary Digital Publishing Institute (MDPI)
Molecules
2025#30Issue 24
An important aspect of food technology is that vitamin compounds can be used for a variety of purposes, such as developing methods to enhance the nutritional value of foods. This paper discusses the synthesis and properties of β-cyclodextrin (β-CD)-functionalized silver nanoparticles, and the use of the resulting β-CD-AgNP inclusion complex when loading vitamin D3 (cholecalciferol, VD3) molecules. β-Cyclodextrin was used as a reducing agent and a stabilizer in the production of silver nanoparticles. The preparation of VD3-β-CD-AgNP nanocompositions was confirmed by UV spectroscopy, transmission electron microscopy, and X-ray diffraction spectroscopy. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) revealed that the resulting β-CD-VD3-AgNP nanocomposite was well dispersed with particle sizes ranging from 6 to 15 nm. 1H-, 13C-NMR and FTIR spectroscopy showed the reduction of silver ions and the formation of β-CD-encapsulated AgNPs. The kinetic parameters of the thermal decomposition reaction of the VD3-β-CD-AgNP nanocomposition have been determined under nonisothermal conditions that ensure the preservation of the kinetic triplet and a more accurate description of the process. The nanocomposition of VD3 with silver nanoparticles demonstrated antibacterial activity against the used bacteria.
antibacterial activity , cholecalciferol , encapsulation , inclusion complex , nanocomposition , silver nanoparticles , thermogravimetry , vitamin D3 , β-cyclodextrin
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Department of Internal Diseases, Karaganda Medical University, Karaganda, 100012, Kazakhstan
Institute of Organic Synthesis and Coal Chemistry, Karaganda, 100008, Kazakhstan
Department of Technology of Food and Processing Industries, Saken Seifullin Kazakh Agrotechnical University, Astana, 010000, Kazakhstan
Department of Physical and Analytical Chemistry, Chemistry Faculty, Academician Ye.A. Buketov Karaganda University, Karaganda, 100024, Kazakhstan
Laboratory of Engineering Profile NMR, Sh. Ualikhanov Kokshetau University, Kokshetau, 020000, Kazakhstan
Department of Technology and Standardization, Kazakh University of Technology and Business, Astana, 010000, Kazakhstan
Department of Biomedicine, Karaganda Medical University, Karaganda, 100012, Kazakhstan
Department of Internal Diseases
Institute of Organic Synthesis and Coal Chemistry
Department of Technology of Food and Processing Industries
Department of Physical and Analytical Chemistry
Laboratory of Engineering Profile NMR
Department of Technology and Standardization
Department of Biomedicine
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