1D and 2D NMR spectroscopy for identification of carbamide-containing biologically active compounds
Мочевина құрамындағы биологиялық белсенді қосылыстарды анықтауға арналған 1D және 2D NMR спектроскопиясы
1D и 2D ЯМР-спектроскопия для идентификации карбамидсодержащих биологически активных соединений
Bakibaev A.A. Panshina S.Yu. Ponomarenko O.V. Malkov V.S. Kotelnikov O.A. Tashenov A.K.
2021E.A.Buketov Karaganda State University Publish House
Bulletin of the Karaganda University Chemistry Series
2021#17Issue 171 - 81 pp.
Urea (carbamide) is the main end product of amino acids metabolism in mammals. Extensive research in the field of urea chemistry has contributed to the creation of many biologically active and other compounds based on the carbamide fragment NH–CO–NH. The substituting groups of urea directly affect its properties and characteristics which are reflected in the NMR spectral data and this circumstance can be the basis for the identification of urea derivatives. In this work, chemical shifts in the NMR spectra of urea and its acyclic structure, barbituric series, imidazolidinone series and bicyclic structure derivatives were studied and identified. A system analysis was carried out to determine the effect of the type of substituents on the positions of signals of the NH-CO-NH fragment in the NMR spectra. The possibility of 2D NMR spectroscopy using to simplify the identification procedure for complex mixtures was shown in the paper. The combined use of 1D and 2D NMR spectroscopy is convenient and informative to establish the structure of biologically active compounds. These methods make it possible to determine the presence and type of impurities, as well as to establish the destruction processes leading to the corresponding impurities.
Barbiturates , Glycoluril , Hydrolysates , Imidazolidinone , Impurities , NMR spectroscopy , Urea , Urea-containing compounds
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National Research Tomsk State University, Tomsk, Russian Federation
National Research Tomsk Polytechnic University, Tomsk, Russian Federation
L.N. Gumilyov Eurasian National University, Nur-Sultan, Kazakhstan
Laboratory of Organic Synthesis, National Research Tomsk State University, Lenin str., 36, Tomsk, 634050, Russian Federation
Analyst of the Laboratory of Organic Synthesis, National Research Tomsk Polytechnic University, Lenin str., 30, Tomsk, 634050, Russian Federation
National Research Tomsk State University, Lenin str., 36, Tomsk, 634050, Russian Federation
L.N. Gumilyov Eurasian National University, Satpaeva str., 2, Nur-Sultan, 010000, Kazakhstan
Head of the, Laboratory of Organic Synthesis, National Research Tomsk State University, Lenin str., 36, Tomsk, 634050, Russian Federation
Laboratory of Organic Synthesis, National Research Tomsk State University, Lenin str., 36, Tomsk, 634050, Russian Federation
Department of Chemistry, L.N. Gumilyov Eurasian National University, Satpaeva str., 2, Nur-Sultan, 010000, Kazakhstan
National Research Tomsk State University
National Research Tomsk Polytechnic University
L.N. Gumilyov Eurasian National University
Laboratory of Organic Synthesis
Analyst of the Laboratory of Organic Synthesis
National Research Tomsk State University
L.N. Gumilyov Eurasian National University
Head of the
Laboratory of Organic Synthesis
Department of Chemistry
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