Metabolomics in neonatal sepsis: A critical appraisal of current evidence
Baizhanova A. Makhammajanov Z. Galiyeva D. Mironova O. Gaipov A. Sazonov V.
January 2025Elsevier B.V.
Computational and Structural Biotechnology Journal
2025#274459 - 4468 pp.
Neonatal sepsis remains a leading cause of morbidity and mortality worldwide; however, timely and accurate diagnosis continues to present a significant clinical challenge. Current diagnostic methods, including blood culture and inflammatory markers, are limited by delayed turnaround times and a lack of specificity, often leading to overtreatment or missed opportunities for intervention. In recent years, metabolomics has emerged as a promising approach for discovering novel biomarkers that reflect the systemic metabolic disruptions characteristic of neonatal sepsis. This systematic review summarizes the existing evidence on changes in metabolites and metabolite classes associated with neonatal sepsis, with a focus on their potential as biomarkers. Eleven eligible studies were reviewed, covering various analytical techniques and biofluids, including serum, urine, and stool. Although a wide range of metabolite alterations was observed, particular attention was given to amino acid metabolism, energy substrates, and lipid derivatives. The findings emphasize both the potential and current limitations of metabolomics-based biomarker discovery in this area. The review identifies important gaps in the literature, including diverse study designs, small sample sizes, and inconsistent reporting, highlighting the need for rigorous, standardized research. The importance and clinical potential of metabolomics in neonatal sepsis are thoroughly discussed.
Metabolomics , Neonatal sepsis , Omics technology , Sepsis
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Department of Medicine, School of Medicine, Nazarbayev University, Astana, Z05K4F4, Kazakhstan
Department of Biomedical Sciences, School of Medicine, Nazarbayev University, Astana, Z05K4F4, Kazakhstan
Pediatric Anesthesiology and Intensive Care Unit, National Research Center for Maternal and Child Health, “University Medical Center”, Astana, Z05K4F4, Kazakhstan
Department of Surgery, School of Medicine, Nazarbayev University, Astana, Z05K4F4, Kazakhstan
Department of Medicine
Department of Biomedical Sciences
Pediatric Anesthesiology and Intensive Care Unit
Department of Surgery
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