Predictors of cirrhosis in chronic hepatitis C: Findings from a 24-month follow-up study in Almaty, Kazakhstan
Baimukhanova M. Kurmanova G. Trimova G. Serikbayeva Z. Aliftenova N. Nurgaliyeva B. Kazbekova A. Amirtayeva S. Sultankulov D. Sadykova S.
15 December 2025Mattioli 1885
Acta Biomedica
2025#96Issue 6
Background and aim: Hepatitis C virus (HCV) infection remains a significant global health challenge, affecting an estimated 50 million people worldwide and causing approximately 1 million new cases annually. The presence of cirrhosis and diabetes mellitus appear to amplify the clinical and economic impact of HCV related disease. This study aims to evaluate the incidence of liver cirrhosis within a 24‑month follow‑up period after HCV diagnosis, as well as its association with diabetes and other prognostic factors. Methods: We performed a retrospective analysis of adults with chronic HCV in Almaty, Kazakhstan, using surveillance and medical record data through December 2024. Eligible patients (ICD‑10 B18.2) had ≥24 months of follow‑up and were assessed for cirrhosis (FibroScan F4) in relation to demographic, clinical, and laboratory factors, including diabetes. Group comparisons and logistic regression identified independent predictors, with statistical significance set at p < 0.05. Results and Conclusions: In patients with chronic HCV in Almaty, Kazakhstan, diabetes, poor glycemic control, elevated GGT, and low platelet count were independent predictors of cirrhosis, while sustained virological response was protective. These findings highlight the need for integrated antiviral and metabolic management, with tailored monitoring for high‑risk patients to reduce disease progression beyond existing dispanserization measures. (www.actabiomedica.it)
Chronic hepatitis C , Cirrhosis , Diabetes mellitus , Follow-up study , Glycemic control , Kazakhstan , Liver disease progression , Predictors , Risk factors , Sustained virological response
Text of the article Перейти на текст статьи
Department of Internal Medicine, Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Propaedeutic of Internal Diseases, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
Department of Biostatistics and Epidemiology, Kazakhstan’s Medical University “KSPH”, Almaty, Kazakhstan
Department of Obstetrics and Gynecology, Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Health Policy and Management, Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University, Almaty, Kazakhstan
Department of Internal Medicine
Department of Propaedeutic of Internal Diseases
Department of Biostatistics and Epidemiology
Department of Obstetrics and Gynecology
Department of Health Policy and Management
10 лет помогаем публиковать статьи Международный издатель
Книга Публикация научной статьи Волощук 2026 Book Publication of a scientific article 2026