An alternative radiochemical separation strategy for isolation of Ac and Ra isotopes from high energy proton irradiated thorium targets for further application in Targeted Alpha Therapy (TAT)

Baimukhanova A. Engudar G. Marinov G. Kurakina E. Dadakhanov J. Karaivanov D. Yang H. Ramogida C.F. Schaffer P. Magomedbekov E.P. Filosofov D. Radchenko V.
1 September 2022 Elsevier Inc.

Nuclear Medicine and Biology
2022 #112-113 35 - 43 pp.

Targeted Alpha Therapy (TAT) has shown very high potential for the treatment of cancers that were not responsive to other therapy options (e.g., β⁻ therapy and chemotherapy). The main constraint to the widespread use of TAT in clinics is the limited availability of alpha-emitting radionuclides. One of the most promising candidates for TAT is ²²⁵Ac (t_1/2 = 9.92 days), which can be used directly in combination with selective biomolecules (e.g., antibodies, peptides, etc.) or be a generator source of ²¹³Bi (t_1/2 = 45.6 min), another shorter-lived TAT radionuclide. Several strategies are currently under investigation to increase the supply of ²²⁵Ac. One of the most attractive options is the irradiation of natural thorium-232 targets with high-energy protons (≥100 MeV). However, there are several challenges associated with this production method including the development of an efficient radiochemical purification method. During irradiation of natural thorium with proton energy above 100 MeV, several Ra isotopes (^223,224,225Ra) are produced. ²²³Ra (t_1/2 = 11.43 days) is used for the treatment of bone metastases and can also be used as a generator source for ²¹¹Pb. Additionally, ²²⁵Ra (t_1/2 = 14.9 days) can be a valuable source of isotopically pure ²²⁵Ac. In the present work, we address the radiochemical separation aspects of isolating Ac and Ra isotopes from irradiated thorium targets.

^223/225Ra , ²²⁵Ac , Cation exchange , DN resin , Natural thorium metal , Spallation , SR resin , Thorium chelation , Trichloroacetic acid

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Laboratory of Nuclear Problems, Joint Institute for Nuclear Research, Joliot-Curie St. 6, Dubna, 141980, Russian Federation
Scientific and Technical Center of Radiochemistry and Isotopes Production, Institute of Nuclear Physics, Ibragimov St. 1, Almaty, 050032, Kazakhstan
Department of High-Energy Chemistry and Radioecology, D. Mendeleev University of Chemical Technology of Russia, Moscow, 125047, Russian Federation
Life Sciences Division, TRIUMF, 4004 Wesbrook Mall, Vancouver, V6T 2A3, Canada
Faculty of Chemistry and Pharmacy, University of Sofia, Blvd “James Bourchier”, Sofia, 1164, Bulgaria
Institute for Nuclear Research and Nuclear Energy, Bulgarian Academy of Sciences, Tsarigradsko shose 72, Sofia, 1784, Bulgaria
Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, V5A 0A7, BC, Canada
Department of Radiology, University of British Columbia, 2775 Lauret St., Vancouver, V5Z 1M9, BC, Canada
Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, V6T 1Z1, BC, Canada

Laboratory of Nuclear Problems
Scientific and Technical Center of Radiochemistry and Isotopes Production
Department of High-Energy Chemistry and Radioecology
Life Sciences Division
Faculty of Chemistry and Pharmacy
Institute for Nuclear Research and Nuclear Energy
Department of Chemistry
Department of Radiology
Department of Chemistry

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